Browsing Terveystieteiden tiedekunta by Title
Now showing items 596-615 of 1735
-
Farmakogeneettiset testit lääkehoidon tukena
(Suomalainen lääkäriseura Duodecim, 2021)Perinnölliset tekijät vaikuttavat useiden lääkehoitojen tehoon ja turvallisuuteen. Perimän on arvioitu selittävän 20-30 % poikkeavista lääkevasteista. Siten huomattava osa yksilöistä on perimänsä vuoksi pysyvästi riskiryhmässä ...Tieteelliset aikakauslehtiartikkelit
-
Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
(Springer Nature, 2017)Nonalcoholic fatty liver disease is one of the most prevalent metabolic disorders and it tightly associates with obesity, type 2 diabetes, and cardiovascular disease. Reduced mitochondrial lipid oxidation contributes to ...info:eu-repo/semantics/article
-
Fast-tracking for total knee replacement reduces use of institutional care without compromising quality
(Informa UK Limited, 2018)Background and purpose — Fast-tracking shortens the length of the primary treatment period (length of stay, LOS) after total knee replacement (TKR). We evaluated the influence of the fast-track concept on the length of ...info:eu-repo/semantics/article
-
Faster to First-time-in-Human: Prediction of the liquid solid ratio for continuous wet granulation
(Elsevier B.V., 2022)In early development, when active pharmaceutical ingredient (API) is in short supply, it would be beneficial to reduce the number of experiments by predicting a suitable L/S ratio before starting the product development. ...
-
Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine
(Oxford University Press (OUP), 2016)Aims To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles. Methods ...info:eu-repo/semantics/article
-
Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes
(American Diabetes Association, 2019)Low 25-hydroxyvitamin D levels correlate with the prevalence of diabetes; however, the mechanisms remain uncertain. Here, we show that nutritional deprivation–responsive mechanisms regulate vitamin D metabolism. Both fasting ...Tieteelliset aikakauslehtiartikkelit
-
Fatal complications after an interrupted gastric bypass operation in a patient with non-alcoholic fatty liver disease and massive obesity: a case report
(Oxford University Press (OUP), 2021)Obesity is closely linked to non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (NASH), the latter now being the most common cause of cirrhosis in Western countries. Only a few cases have been described, ...Tieteelliset aikakauslehtiartikkelit
-
Fatigue resistance of metal-free cantilever bridges supported by labial laminate veneers
(Elsevier BV, 2020)Tieteelliset aikakauslehtiartikkelit
-
Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies
(Public Library of Science (PLoS), 2018)Background We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with ...Tieteelliset aikakauslehtiartikkelit
-
Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration
(Elsevier BV, 2019)Retinal pigment epithelium (RPE) damage is a primary sign in the development of age-related macular degeneration (AMD) the leading cause of blindness in western countries. RPE cells are exposed to chronic oxidative stress ...Tieteelliset aikakauslehtiartikkelit
-
Fearful dogs have increased plasma glutamine and gamma-glutamyl glutamine
(Springer Nature America, Inc, 2018)Anxiety-related disorders, including fearfulness are common and leading welfare problems among the worldwide dog population. The etiology of anxieties is complex and affected by genetic and environmental factors. Thus, ...Tieteelliset aikakauslehtiartikkelit
-
Feasibility of a checklist in treating hypertension in primary care - base line results from a cluster-randomised controlled trial (check and support
(Springer Nature, 2018)Background Most patients with antihypertensive medication do not achieve their blood pressure (BP) target. The most important factor behind this failure is poor medication adherence. However, non-adherence to therapy does ...Tieteelliset aikakauslehtiartikkelit
-
Feature Set Optimization in Biomarker Discovery From Genome Scale Data
(Oxford University Press (OUP), 2020)Motivation Omics technologies have the potential to facilitate the discovery of new biomarkers. However, only few omics-derived biomarkers have been successfully translated into clinical applications to date. Feature ...Tieteelliset aikakauslehtiartikkelit
-
Febrile neutropenia in patients with acute myeloid leukemia: outcome in relation to qSOFA score, C-reactive protein and blood culture findings
(Wiley, 2020)Objectives To evaluate quick Sequential Organ Failure Assessment (qSOFA) score during febrile neutropenia (FN) in adult patients receiving intensive chemotherapy for acute myeloid leukemia (AML). Methods qSOFA score, ...Tieteelliset aikakauslehtiartikkelit
-
FGF21 Contributes to Metabolic Improvements Elicited by Exenatide and Pioglitazone in Patients with Type 2 Diabetes
(American Physiological Society, 2022)Fibroblast growth factor 21 (FGF21) is increased acutely by carbohydrate ingestion and is elevated in patients with type 2 diabetes (T2D). However, the physiological significance of increased FGF21 in humans remains largely ...
-
FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells
(The American Heart Association, 2023)Background: Genome-wide association studies have identified hundreds of loci associated with common vascular diseases, such as coronary artery disease, myocardial infarction, and hypertension. However, the lack of mechanistic ...
-
Fibroblast Growth Factor 21, Adiponectin, and Irisin as Markers of Unfavorable Metabolic Features in 12-Year-Old Children
(The Endocrine Society, 2019)Context Among cytokines, fibroblast growth factor 21 (FGF21), adiponectin (Adn), and irisin have been considered potential biomarkers for insulin sensitivity (IS). Objective We evaluated whether serum FGF21, Adn, and ...Tieteelliset aikakauslehtiartikkelit
-
Financial cost of elective day of surgery cancellations
(Sciedu Press, 2018)Operative care is one of the major areas of healthcare services as over 310 million surgeries are conducted yearly. Surgery cancellations is a widely used indicator when evaluating the quality of preoperative care. ...Tieteelliset aikakauslehtiartikkelit
-
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)
(Springer Nature, 2016)Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis ...info:eu-repo/semantics/article
-
Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus
(Public Library of Science (PLoS), 2016)The Cancer Genetic Markers of Susceptibility genome-wide association study (GWAS) originally identified a single nucleotide polymorphism (SNP) rs11249433 at 1p11.2 associated with breast cancer risk. To fine-map this locus, ...info:eu-repo/semantics/article