Now showing items 631-650 of 1052

    • Melanocyte hyaluronan coat fragmentation enhances the UVB-induced TLR-4 receptor signaling and expression of proinflammatory mediators IL-6, IL-8, CXCL-1 and CXCL-10 via NF-kappaB activation 

      Takabe, P; Kärnä, R; Rauhala, L; Tammi, M; Tammi, R; Pasonen-Seppänen, S (Elsevier BV, 2019)
      Skin is constantly exposed to UVR, the most critical risk factor for melanoma development. Hyaluronan is abundant in the epidermal extracellular matrix and may undergo degradation by UVR. It is hypothesized that an intact ...
    • Melatonin receptor type 1A gene linked to Alzheimer's disease in old age 

      Sulkava, S; Muggalla, P; Sulkava, R; Ollila, HM; Peuralinna, T; Myllykangas, L; Kaivola, K; Stone, DJ; Traynor, BJ; Renton, AE; Rivera, AM; Helisalmi, S; Soininen, H; Polvikoski , T; Hiltunen, M; Tienari, PJ; Huttunen, HJ; Paunio, T (Oxford University Press (OUP)Yhdysvallat (USA), 2018)
      Disruption of the circadian rhythms is a frequent preclinical and clinical manifestation of Alzheimer’s disease. Furthermore, it has been suggested that shift work is a risk factor for Alzheimer’s disease. Previously, we ...
    • Melphalan 140 mg/m2 or 200 mg/m2 for autologous trasnplantation in myeloma: results from the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study. A report by the EBMT Chronic Malignancies Working Party 

      Auner, Holger W; Iacobelli, Simona; Sbianchi, Giulia; Knol-Bout, Cora; Blaise, Didier; Russell, Nigel H; Apperley, Jane F; Pohlreich, David; Browne, Paul V; Kobbe, Guido; Isaksson, Cecilia; Lenhoff, Stig; Scheid, Christof; Touzeau, Cyrille; Jantunen, Esa; Anagnostopoulos, Achilles; Yakoub-Agha, Ibrahim; Tanase, Alina; Schaap, Nicolaas; Wiktor-Jedrzejczak, Wieslaw; et al. (Ferrata Storti Foundation (Haematologica)Italia, 2018)
      Melphalan at a dose of 200 mg/m2 is standard conditioning prior to autologous hematopoietic stem cell transplantation for multiple myeloma, but a dose of 140 mg/m2 is often used in clinical practice in patients perceived ...
    • Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer 

      Jarvis D; Mitchell JS; Law PJ; Palin K; Tuupanen S; Gylfe A; Hänninen UA; Cajuso T; Tanskanen T; Kondelin J; Kaasinen E; Sarin A-P; Kaprio J; Eriksson JG; Rissanen H; Knekt P; Pukkala E; Jousilahti P; Salomaa V; Ripatti S; Palotie A; Järvinen H; Renkonen-Sinisalo L; Lepistö A; Böhm J; Meklin J-P; Al-Tassan NA; Palles C; Martin L; Barclay E; Farrington SM; Timofeeva MN; Meyer BF; Wakil SM; Campbell H; Smith C.G; Idziaszczyk S; Maughan TS; Kaplan R; Kerr R; Kerr D; Buchanan DD; Win AK; Hopper JL; Jenkins MA; Lindor NM; Newcomb PA (Cancer Research UK, 2016-06-23)
      Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed ...
    • Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy 

      Srivastava, Prashant K; Roncon, Paolo; Lukasiuk, Katarzyna; Gorter, Jan A; Aronica, Eleonora; Pitkänen, Asla; Petretto, Enrico; Johnson, Michael R; Simonato, Michele (Society for Neuroscience, 2017)
      The identification of mechanisms transforming normal to seizure-generating tissue after brain injury is key to developing new antiepileptogenic treatments. MicroRNAs (miRNAs) may act as regulators and potential treatment ...
    • Metabolic characterization of menopause: cross-sectional and longitudinal evidence 

      Wang, Q; Ferreira, DLS; Nelson, SM; Sattar, N; Ala-Korpela, M; Lawlor, DA (Springer Nature, 2018)
      Background Women who experience menopause are at higher cardiometabolic risk and often display adverse changes in metabolic biomarkers compared with pre-menopausal women. It remains elusive whether the changes in ...
    • Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle-Aged Finnish Men 

      Noerman, S; Kärkkäinen, O; Mattsson, A; Paananen, J; Lehtonen, M; Nurmi, T; Tuomainen, TP; Voutilainen, S; Hanhineva, K; Virtanen, JK (WileySaksa, 2018)
      Scope Higher egg intake was previously associated with a lower risk of developing type 2 diabetes (T2D) in the prospective, population‐based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) in eastern Finland. ...
    • Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity 

      Couto Alves A; Valcarcel B; Mäkinen VP; Morin-Papunen L; Sebert S; Kangas AJ; Soininen P; Das S; De Iorio M; Coin L; Ala-Korpela M; Järvelin MR; Franks S (Springer Nature, 2017)
      Background: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance and diabetes mellitus. Here we investigate whether changes in ...
    • Metabolic profiling of sourdough fermented wheat and rye bread. 

      Koistinen VM; Mattila O; Katina K; Poutanen K; Aura AM; Hanhineva (Springer Nature, 2018)
      Sourdough fermentation by lactic acid bacteria is commonly used in bread baking, affecting several attributes of the final product. We analyzed whole-grain wheat and rye breads and doughs prepared with baker’s yeast or a ...
    • Metabolism of Scoparone in Experimental Animals and Humans 

      Juvonen, RO; Novák, F; Emmanouilidou, E; Auriola, S; Timonen, J; Heikkinen, AT; Küblbeck, J; Finel, M; Raunio, H (Georg Thieme Verlag KGSaksa, 2019)
      Scoparone, a major constituent of the Chinese herbal medicine Yin Chen Hao, expresses beneficial effects in experimental models of various diseases. The intrinsic doses and effects of scoparone are dependent on its metabolism, ...
    • Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment 

      Sliz, E; Kettunen, J; Holmes, MV; Williams, CO; Boachie, C; Wang, Q; Mannikko, M; Sebert, S; Walters, R; Lin, K; Millwood, IY; Clarke, R; Li, L; Rankin, N; Welsh, P; Delles, C; Jukema, JW; Trompet, S; Ford, I; Perola, M et al. [Incl. Ala-Korpela, M] (American Heart Association, Inc, 2018)
      Background: Both statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors lower blood low-density lipoprotein cholesterol levels to reduce risk of cardiovascular events. To assess potential differences ...
    • Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase 

      Würtz, Peter; Wang, Qin; Soininen, Pasi; Kangas, Antti J; Fatemifar, Ghazaleh; Tynkkynen, Tuulia; Tiainen, Mika; Perola, Markus; Tillin, Therese; Hughes, Alun D; Mäntyselkä, Pekka; Kähönen, Mika; Lehtimäki, Terho; Sattar, Naveed; Hingorani, Aroon D; Casas, Juan-Pablo; Salomaa, Veikko; Kivimäki, Mika; Järvelin, Marjo-Riitta; Davey Smith George et al (Elsevier Inc.; American College of Cardiology, 2016)
      Background Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized. O ...
    • metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis 

      Cichonska Anna; Rousu Juho; Marttinen Pekka; Kangas Antti J; Soininen Pasi; Lehtimäki Terho; Raitakari Olli T; Järvelin Marjo-Riitta; Salomaa Veikko; Ala-Korpela Mika; Ripatti Samuli; Pirinen Matti (Oxford University Press (OUP), 2016)
      Motivation A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. However, analyzing related traits together increases statistical power, and certain complex ...
    • Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles 

      Lazaro-Ibanez Elisa; Neuvonen Maarit; Takatalo Maarit; Arasu Uma Thanigai; Capasso Cristian; Cerullo Vincenzo; Rhim Johng S; Rilla Kirsi; Yliperttula Marjo; Siljander Pia R -M (Informa UK Limited, 2017)
      Extracellular vesicles (EVs), including microvesicles and exosomes, mediate intercellular signalling which has a profound role in cancer progression and in the development of metastasis. Internalisation of EVs can prompt ...
    • Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity 

      Markowicz-Piasecka Magdalena; Sikora Joanna; Mateusiak Lukasz; Mikiciuk-Olasik Elzbieta; Huttunen Kristiina M (Hindawi Limited, 2017)
      The results of epidemiological and pathophysiological studies suggest that type 2 diabetes mellitus (T2DM) may predispose to Alzheimer’s disease (AD). The two conditions present similar glucose levels, insulin resistance, ...
    • Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation 

      Markowicz-Piasecka, M; Huttunen, KM; Sikora, J (Informa UK Limited, 2018)
      The aim of this study was to assess in vitro the effects of sulphenamide and sulphonamide derivatives of metformin on the activity of human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), establish the type ...
    • Methods of surgery for pelvic organ prolapse in a nationwide Cohort (FINPOP 2015) 

      Mattsson, NK; Karjalainen, P; Tolppanen, AM; Heikkinen, AM; Jalkanen, J; Härkki, P; Nieminen K (WileyTanska, 2019)
      Introduction The management of pelvic organ prolapse (POP) varies significantly between countries. The objective of this study was to describe the methods used for POP surgery in Finland and to identify the factors that ...
    • MicroRNA Profiling Reveals Distinct Profiles for Tissue-Derived and Cultured Endothelial Cells 

      Kuosmanen Suvi M; Kansanen Emilia; Sihvola Virve; Levonen Anna-Liisa (Springer Nature, 2017)
      Endothelial plasticity enables the cells to switch their phenotype according to the surrounding vascular microenvironment. MicroRNAs (miRNAs) are small noncoding RNAs that control endothelial plasticity. The objective of ...
    • MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells 

      Kuosmanen, SM; Sihvola, V; Kansanen, E; Kaikkonen, MU; Levonen, AL (Elsevier BV, 2018)
      Oxidative stress predisposes to several aging-associated diseases, such as cardiovascular diseases and cancer. In aging, increase in the production of reactive oxygen species is typically accompanied with a decline in ...
    • Midlife Work-Related Stress is Associated with Late-Life Gray Matter Volume Atrophy 

      Sindi, Shireen; Kåreholt, Ingemar; Spulber, Gabriela; Soininen, Hilkka; Kivipelto, Miia; Solomon, Alina (IOS Press, 2017)
      Background: Work-related stress has been associated with an increased dementia risk. However, less is known about the mechanisms that underlie these associations. Objective: The goal is to examine associations between ...