Now showing items 631-650 of 1008

    • Mielipiteitä sähköisen reseptin tietosuojasta - kyselytutkimus apteekkien asiakkaille 

      Rattay, Kim; Kauppinen, Hanna; Ahonen, Riitta; Timonen, Johanna (Suomi, 2018)
      Johdanto: Sähköinen resepti on Suomessa laajamittaisessa käytössä. Reseptitiedot ovat arkaluontoisia terveystietoja, joten potilailla tulee olla luottamus yksityisyydensuojaan ja reseptitietojensa asianmukaiseen käyttöön. ...
    • miRandola 2017: a curated knowledge base of non-invasive biomarkers 

      Russo F; Di Bella S; Vannini F; Berti G; Scoyni F; Cook HV; Santos A; Nigita G; Bonnici V; Laganà A; Geraci F; Pulvirenti A1; Giugno R; De Masi F; Belling K; Jensen LJ; Brunak SR; Pellegrini M; Ferro A (Oxford University Press (OUP), 2017)
      miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of ...
    • Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes 

      Lampinen, Riikka; Belaya, Irina; Boccuni, Isabella; Malm, Tarja; Kanninen, Katja M (InTech, 2018)
      The brain is one of the most energy-requiring organs in the human body. Mitochondria not only generate this energy, but are centrally involved critical cellular functions including maintenance of calcium homeostasis, ...
    • Mitochondrial genes are altered in blood early in Alzheimer's disease 

      Lunnon K; Keohane A; Pidsley R; Newhouse S; Riddoch-Contreras J; Thubron EB; Devall M; Soininen H; Kloszewska I; Mecocci P; Tsolaki M; Vellas B; Schalkwyk L; Dobson R; Malik AN; Powell J; Lovestone S; Hodges A (Elsevier BVYhdysvallat (USA), 2017)
      Although mitochondrial dysfunction is a consistent feature of Alzheimer's disease in the brain and blood, the molecular mechanisms behind these phenomena are unknown. Here we have replicated our previous findings demonstrating ...
    • Mitochondrial quality control in AMD: does mitophagy play a pivotal role? 

      Hyttinen, Juha MT; Viiri, Johanna; Kaarniranta, Kai; Blasiak, Janusz (Springer Nature, 2018)
      Age-related macular degeneration (AMD) is the predominant cause of visual loss in old people in the developed world, whose incidence is increasing. This disease is caused by the decrease in macular function, due to the ...
    • Modified internal mammary artery perforator flap in treatment of sternal wound complications 

      Myllykangas, Heidi-Mari P; Mustonen, Paula K; Halonen, Jari K; Berg, Leena T (Informa UK Limited, 2019)
      Objectives. There are multiple treatment strategies and flap options to cover defects after deep sternal wound infections and other similar sternal defects. The choice of flap is made according to surgeons’ preferences and ...
    • Modified serpinA1 as risk marker for Parkinson's disease dementia: analysis of baseline data 

      Halbgebauer, Steffen; Nagi, Magdalena; Klafki, Hans; Haußmann, Ute; Steinacker, Petra; Oeckl, Patrick; Kassubek, Jan; Pinkhardt, Elmar; Ludolph, Albert C; Soininen, Hilkka; Herukka, Sanna-Kaisa; Wiltfang, Jens; Otto, Markus (Springer Nature, 2016)
      Early detection of dementia in Parkinson disease is a prerequisite for preventive therapeutic approaches. Modified serpinA1 in cerebrospinal fluid (CSF) was suggested as an early biomarker for differentiation between ...
    • Modulation of motor cortical excitability with auditory stimulation 

      Löfberg, Olli; Julkunen, Petro; Kallioniemi, Elisa; Pääkkönen, Ari; Karhu, Jari (American Physiological Society, 2018)
      Loud sounds have been demonstrated to increase motor cortex excitability when transcranial magnetic stimulation (TMS) is synchronized with auditory evoked N100 potential measured from electroencephalography (EEG). The N100 ...
    • Modulation of sphingosine receptors influences circadian pattern of cardiac autonomic regulation 

      Simula Sakari; Laitinen Tomi P; Laitinen Tiina M; Hartikainen Päivi; Hartikainen Juha EK (Wiley-Blackwell, 2016)
      Fingolimod is an oral sphingosine‐1‐phospate (S1P) receptor modulator for the treatment of relapsing‐remitting multiple sclerosis (RRMS). In addition to therapeutic effects on lymphoid and neural tissue, fingolimod influences ...
    • Modulation of vitamin D signaling by the pioneer factor CEBPA 

      Nurminen, Veijo; Neme, Antonio; Seuter, Sabine; Carlberg, Carsten (Elsevier BVAlankomaat, 2019)
      The myeloid master regulator CCAAT enhancer-binding protein alpha (CEBPA) is known as a pioneer factor. In this study, we report the CEBPA cistrome of THP-1 human monocytes after stimulation with the vitamin D receptor ...
    • Molecular endocrinology of vitamin D on the epigenome level 

      Carlberg Carsten (Elsevier BV, 2017)
      The molecular endocrinology of vitamin D is based on the facts that i) its metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the nuclear receptor vitamin D receptor (VDR) and ii) the ...
    • Molecular Forms and Fragments of Salivary MMP-8 in Relation to Periodontitis 

      Gürsoy, Ulvi K; Könönen, Eija; Tervahartiala, Taina; Gürsoy, Mervi; Pitkänen, Jari; Torvi, Paula; Suominen, Anna Liisa; Pussinen, Pirkko; Sorsa, Timo (WileyTanska, 2018)
      Aim To investigate the molecular forms of salivary matrix metalloproteinase (MMP)‐8 in relation to periodontitis. Materials and Methods Molecular forms, degree of activation and fragmentation of neutrophilic and ...
    • Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease 

      Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko (Frontiers Media SA, 2018)
      Alzheimer’s disease (AD) is the most common neurodegenerative disorder, which is clinically associated with a global cognitive decline and progressive loss of memory and reasoning. According to the prevailing amyloid cascade ...
    • Molecular Mechanisms Underlying Age-Related Ocular Diseases 

      Amadio, M; Kaarniranta, K; Xu, H; Smedowski, A; Ferrington, DA (Hindawi Limited, 2018)
    • Molecular targets of chloropicrin in human airway epithelial cells 

      Pesonen M; Rysä J; Storvik M; Rilla K; Pasanen M; Vähäkangas K (Elsevier BV, 2017)
      Chloropicrin is a vaporizing, irritating compound that causes complications in the respiratory system when inhaled. In this study, we examined the effects of exposure to chloropicrin for 24 h on ultrastructure and global ...
    • Moniammatilliset simulaatiot opettajien vinkkelistä 

      Silén-Lipponen, Marja; Metsävainio, Kirsimarja; Saaranen, Terhi (Akavan sairaanhoitajat ja TAJA ry, 2018)
      Sosiaali- ja terveydenhuollon työntekijöiltä odotetaan tiivistä yhteistyötä potilaiden yhä monimutkaisempien terveysongelmien ratkaisemiseksi. Moniammatillisen yhteistyön vaatimus kasvaa. Parhaimmillaan se onkin sujuvaa ...
    • Month and Season of Birth as a Risk Factor for Alzheimer's Disease: A Nationwide Nested Case-control Study 

      Tolppanen, Anna-Maija; Ahonen, Riitta; Koponen, Marjaana; Lavikainen, Piia; Purhonen, Maija; Taipale, Heidi; Tanskanen, Antti; Tiihonen, Jari; Tiihonen, Miia; Hartikainen, Sirpa (Korean Society for Preventive Medicine, 2016)
      Objectives: Season of birth, an exogenous indicator of early life environment, has been related to higher risk of adverse psychiatric outcomes but the findings for Alzheimer’s disease (AD) have been inconsistent. We ...
    • Morphological features of the left atrial appendage in consecutive coronary computed tomography angiography patients with and without atrial fibrillation 

      Korhonen Miika; Parkkonen Johannes; Hedman Marja; Muuronen Antti; Onatsu Juha; Mustonen Pirjo; Vanninen Ritva; Taina Mikko (Public Library of Science (PLoS), 2017)
      The majority of intracardiac thrombi form in the left atrial appendage (LAA). Enlargement of this structure, together with certain morphological features, may indicate a predisposition to the formation of thrombi and ...
    • Mortality due to Vegetation Fire-Originated PM2.5 Exposure in Europe - Assessment for the Years 2005 and 2008 

      Kollanus Virpi; Prank Marje; Gens Alexandra; Soares Joana; Vira Julius; Kukkonen Jaakko; Sofiev Mikhail; Salonen Raimo O; Lanki Timo (National Institute of Environmental Health Sciences (NIEHS), 2017)
      Background: Vegetation fires can release substantial quantities of fine particles (PM2.5), which are harmful to health. The fire smoke may be transported over long distances and can cause adverse health effects over wide ...
    • Motivators, barriers and strategies of weight management: A cross-sectional study among Finnish adults 

      Halali, F; Lapveteläinen, A; Karhunen, L; Saarela, AM; Lappalainen, R; Kantanen, T (Elsevier BVAlankomaat, 2018)
      Background Weight management (WM) is an ongoing global challenge. The purpose of this study was to analyze motivators, barriers, and strategies of WM among Finnish adults. Methods Data were collected in the ‘KULUMA’ ...