Browsing Terveystieteiden tiedekunta by Title

Now showing items 646-665 of 1735

    • Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology 

      Dourlen P; Fernandez-Gomez FJ; Dupont C; Grenier-Boley B; Bellenguez C; Obriot H; Caillierez R; Sottejeau Y; Chapuis J; Bretteville A; Abdelfettah F; Delay C; Malmanche N; Soininen H; Hiltunen M; Galas MC; Amouyel P; Sergeant N; Buée L; Lambert JC; Dermaut B (Springer Nature, 2016)
      A recent genome-wide association meta-analysis for Alzheimer’s disease (AD) identified 19 risk loci (in addition to APOE) in which the functional genes are unknown. Using Drosophila, we screened 296 constructs targeting ...
      info:eu-repo/semantics/article

    • Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia 

      López Rodríguez, Maykel; Fernandes Silva, Lilian; Vangipurapu, Jagadish; Modi, Shalem; Kuusisto, Johanna; Kaikkonen, Minna U; Laakso, Markku (Springer Nature America, Inc, 2018)
      The rs780094 single nucleotide polymorphism (SNP; C/T) of glucokinase regulatory protein gene (GCKR) is a regulatory genetic variant that has been associated with lactate levels in the fasting state. However, the association ...
      Tieteelliset aikakauslehtiartikkelit

    • Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working group on Atherosclerosis and Vascular Biology 

      Caporali, A; Bäck, M; Daemen, MJ; Hoefer, IE; Jones, EA; Lutgens, E; Matter, CM; Bochaton-Piallat, ML; Siekmann, AF; Sluimer, JC; Steffens, S; Tuñón, J; Vindis, C; Wentzel, JJ; Ylä-Herttuala, S; Evans, PC (Oxford University Press (OUP), 2018)
      Modulation of vessel growth holds great promise for treatment of cardiovascular disease. Strategies to promote vascularization can potentially restore function in ischaemic tissues. On the other hand, plaque neovascularization ...
      Tieteelliset aikakauslehtiartikkelit

    • Future of Animal Modeling for Poststroke Tissue Repair 

      Modo, MM; Jolkkonen, J; Zille, M; Boltze, J (Ovid Technologies (Wolters Kluwer Health), 2018)
      Numerous preclinical animal studies have shown beneficial effects of cell therapies after stroke, including reduction of functional deficits and lesion size. Early stage clinical studies currently aim to confirm this ...
      Tieteelliset aikakauslehtiartikkelit

    • Future risk of metabolic syndrome in women with a previous LGA delivery stratified by gestational glucose tolerance: a prospective cohort study 

      Hakkarainen, Heidi; Huopio, Hanna; Cederberg, Henna; Voutilainen, Raimo; Heinonen, Seppo (Springer Nature America, Inc, 2018)
      Background Whether the delivery of a large-for-gestational-age (LGA) infant predicts future maternal metabolic syndrome (MetS) is not known. To this aim, we investigated the incidence of MetS and its components in women ...
      Tieteelliset aikakauslehtiartikkelit

    • Fysiologiset vasteet liikuntaan lapsilla ja nuorilla 

      Haapala, Eero A; Ihalainen, Johanna K (, 2018)
      Lasten ja nuorten vasteet liikuntaan ja liikuntaharjoitteluun ovat osin samankaltaisia kuin aikuisilla. Liikuntaharjoittelun perusperiaatteet kuten ylikuormitus, progressio, spesifisyys ja yksilölliset vasteet sekä ...
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    • Gadoterate meglumine decreases ADC values of breast lesions depending on the b value combination 

      Arponen, O; Sudah, M; Sutela, A; Taina, M; Masarwah, A; Liimatainen, T; Vanninen, R (Springer Nature, 2018)
      To retrospectively evaluated the influence of administration of the gadolinium based intravenous contrast agent (G-CA) on apparent diffusion coefficient (ADC) values in ADC maps generated using multiple b value combinations. ...
      Tieteelliset aikakauslehtiartikkelit

    • Galactography is not an obsolete investigation in the evaluation of pathological nipple discharge 

      Istomin, A; Masarwah, A; Pitkänen, M; Joukainen, S; Sutela, A; Vanninen, R; Sudah, M (Public Library of Science (PLoS), 2018)
      Purpose To evaluate the malignancy rate and diagnostic performance of galactography in patients with pathological nipple discharge (PND) after negative clinical breast examination, mammography and ultrasound. Materials ...
      Tieteelliset aikakauslehtiartikkelit

    • Gambling expenditure by game type among weekly gamblers in Finland 

      Salonen, Anne H; Kontto, Jukka; Perhoniemi, Riku; Alho, Hannu; Castren, Sari (Springer Nature, 2018)
      Background Excessive expenditure and financial harms are core features of problem gambling. There are various forms of gambling and their nature varies. The aim was to measure gambling expenditure by game type while ...
      Tieteelliset aikakauslehtiartikkelit

    • Gastrointestinal Diseases, Genetic Risk, and Incident Dementia: A Prospective Cohort Study in 352,463 Middle-Aged Adults 

      Yuan, Shuai; Dan, Lintao; Zhang, Yao; Wu, Jing; Zhao, Jianhui; Kivipelto, Miia; Chen, Jie; Ludvigsson, Jonas F; Li, Xue; Larsson, Susanna C (Elsevier Inc, 2024)
      Introduction Although digestive system disease affects gut microbiota and their metabolites associated with dementia risk, the association between digestive system diseases and incident dementia has not yet been ...

    • Gene Expression Mapping of Histone Deacetylases and Co-factors, and Correlation with Survival Time and 1H-HRMAS Metabolomic Profile in Human Gliomas subtitle: 

      Dali-Youcef, Nassim; Froelich, Sébastien; Moussallieh, François-Marie; Chibbaro, Salvatore; Noël, Georges; Namer, Izzie J.; Heikkinen, Sami; Auwerx, Johan (Nature Publishing Group, 2015)
      Primary brain tumors are presently classified based on imaging and histopathological techniques, which remains unsatisfaying. We profiled here by quantitative real time PCR (qRT-PCR) the transcripts of eighteen histone ...
      info:eu-repo/semantics/article

    • Gene Expression Profile as a Predictor of Seizure Liability 

      Lipponen, Anssi; Kajevu, Natallie; Natunen, Teemu; Ciszek, Robert; Puhakka, Noora; Hiltunen, Mikko; Pitkänen, Asla (MDPI, 2023)
      Analysis platforms to predict drug-induced seizure liability at an early phase of drug development would improve safety and reduce attrition and the high cost of drug development. We hypothesized that a drug-induced in ...

    • Gene Therapeutic Strategies for Peripheral Artery Disease and New Opportunities Provided by Adeno-Associated Virus Vectors 

      Khachigian, Levon M; Varcoe, Ramon L; Suoranta, Tuisku; Laham-Karam, Nihay; Ylä-Herttuala, Seppo (American Heart Association, Inc, 2023)
      Peripheral artery disease (PAD) is a vascular disorder caused by occlusive atherosclerosis, which commonly impairs blood flow to the lower extremities. The prevalence of PAD is increasing globally with >200 million people ...

    • Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium 

      Barrdahl M; Rudolph A; Hopper JL; Southey MC; Broeks A; Fasching PA; Beckmann MW; Gago-Dominguez M; Castelao JE; Guénel P; Truong T; Bojesen SE; Gapstur SM; Gaudet MM; Brenner H; Arndt V; Brauch H; Hamann U; Mannermaa A; Lambrechts D et al (Wiley-Blackwell, 2017)
      Investigating the most likely causal variants identified by fine-mapping analyses may improve the power to detect gene–environment interactions. We assessed the interplay between 70 single nucleotide polymorphisms identified ...
      info:eu-repo/semantics/article

    • Geneettiset epilepsiat 

      Kälviäinen, Reetta; Saarela, Anni; Lehesjoki, Anna-Elina (Suomen lääkäriliitto, 2022)
      Molekyylitason diagnostiikka on mahdollista monissa harvinaisissa geneettisissä epilepsioissa. Tarkentunut diagnostiikka vaikuttaa valintoihin epilepsian lääkehoidossa. Genominlaajuiset lähestymistavat ovat syrjäyttämässä ...

    • Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene 

      Oksanen, Minna; Hyötyläinen, Ida; Voutilainen, Jenni; Puttonen, Katja A; Hämäläinen, Riikka H; Graff, Caroline; Lehtonen, Šarka; Koistinaho, Jari (Elsevier BV, 2018)
      A double mutation (KM670/671NL) in amyloid precursor protein gene (APP) is causative for familial Alzheimer's disease and has been shown to increase the total Aβ burden. Here we report the generation and characterization ...
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    • Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease 

      Lehtonen, Š; Höytyläinen, I; Voutilainen, J; Sonninen, T-M; Kuusisto, J; Laakso, M; Hämäläinen, RH; Oksanen, M; Koistinaho, J (Elsevier BV, 2018)
      An amyloid precursor protein (APP) A673T mutation was found to be protective against Alzheimer's disease (AD) and cognitive decline in the Icelandic population and to associate with decreased levels of plasma β-amyloid in ...
      Tieteelliset aikakauslehtiartikkelit

    • Genes and Dietary Fatty Acids in Regulation of Fatty Acid Composition of Plasma and Erythrocyte Membrane 

      Lankinen, M; Uusitupa, M; Schwab, U (MDPI AG, 2018)
      The fatty acid compositions of plasma lipids and cell membranes of certain tissues are modified by dietary fatty acid composition. Furthermore, many other factors (age, sex, ethnicity, health status, genes, and gene × diet ...
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    • Genetic architecture of human plasma lipidome and its link to cardiovascular disease 

      Tabassum, Rubina; Ramo, Joel T; Ripatti, Pietari; Koskela, Jukka T; Kurki, Mitja; Karjalainen, Juha; Palta, Priit; Hassan, Shabbeer; Nunez-Fontarnau, Javier; Kiiskinen, Tuomo T J; Söderlund, Sanni; Matikainen, Niina; Gerl, Mathias J; Surma, Michal A; Klose, Christian; Stitziel, Nathan O; Laivuori, Hannele; Havulinna, Aki S; Service, Susan K; Salomaa, Veikko et al. (Incl Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli-Matti; Soininen, Hilkka; Kälviäinen, Reetta) (Springer Science and Business Media LLC, 2019)
      Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species ...
      Tieteelliset aikakauslehtiartikkelit

    • Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept 

      Franke, B; Stein, JL; Ripke, S; Anttila, V; Hibar, DP; van Hulzen, KJ; Arias-Vasquez, A; Smoller, JW; Nichols, TE; Neale, MC; McIntosh, AM; Lee, P; McMahon, FJ; Meyer-Lindenberg, A; Mattheisen, M; Andreassen, OA; Gruber, O; Sachdev, PS; Roiz-Santiañez, R; Saykin, AJ et al (Nature Publishing Group, 2016)
      Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are ...
      info:eu-repo/semantics/article