Now showing items 671-690 of 1052

    • Mortality due to Vegetation Fire-Originated PM2.5 Exposure in Europe - Assessment for the Years 2005 and 2008 

      Kollanus Virpi; Prank Marje; Gens Alexandra; Soares Joana; Vira Julius; Kukkonen Jaakko; Sofiev Mikhail; Salonen Raimo O; Lanki Timo (National Institute of Environmental Health Sciences (NIEHS), 2017)
      Background: Vegetation fires can release substantial quantities of fine particles (PM2.5), which are harmful to health. The fire smoke may be transported over long distances and can cause adverse health effects over wide ...
    • Motivators, barriers and strategies of weight management: A cross-sectional study among Finnish adults 

      Halali, F; Lapveteläinen, A; Karhunen, L; Saarela, AM; Lappalainen, R; Kantanen, T (Elsevier BVAlankomaat, 2018)
      Background Weight management (WM) is an ongoing global challenge. The purpose of this study was to analyze motivators, barriers, and strategies of WM among Finnish adults. Methods Data were collected in the ‘KULUMA’ ...
    • Motoristen taitojen ja lihasvoiman vuorovaikutus lapsuudessa ja nuoruudessa 

      Laukkanen, Arto; Joensuu, Laura; Sääkslahti, Arja; Ihalainen, Johanna K; Huotari, Pertti; Haapala, Eero A (Liikuntatieteellinen Seura rySuomi, 2018)
      Lasten motoriset taidot ja lihasvoima eivät kehity perimän määrittämään täyteen potentiaaliinsa ilman mahdollisuuksia harjoitella liikkumista erilaisissa ympäristöissä ja tilanteissa. Suurin osa varhais- ja keskilapsuuden ...
    • A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission 

      Nielsen J; Fejgin K; Sotty F; Nielsen V; Mørk A; Christoffersen CT; Yavich L; Lauridsen JB; Clausen D; Larsen PH; Egebjerg J; Werge TM; Kallunki P; Christensen KV; Didriksen M (Springer Nature, 2017)
      1q21.1 hemizygous microdeletion is a copy number variant leading to eightfold increased risk of schizophrenia. In order to investigate biological alterations induced by this microdeletion, we generated a novel mouse model ...
    • A Multi-Cohort Study of ApoE e4 and Amyloid-ß Effects on the Hippocampus in Alzheimer's Disease 

      Khan W; Giampietro V; Banaschewski T; Barker GJ; Bokde ALW; Büchel C; Conrod P; Flor H; Frouin V; Garavan H; Gowland P; Heinz A; Ittermann B; Lemaître H; Nees F; Paus T; Pausova Z; Rietschel M; Smolka MN; Ströhle A et al. (IOS PressAlankomaat, 2017)
      The apolipoprotein E (APOE) gene has been consistently shown to modulate the risk of Alzheimer’s disease (AD). Here, using an AD and normal aging dataset primarily consisting of three AD multi-center studies (n = 1,781), ...
    • Multi-omics analysis of ten carbon nanomaterials effects highlights cell type specific patterns of molecular regulation and adaptation 

      Scala, Giovanni; Kinaret, Pia; Marwah, Veer; Sund, Jukka; Fortino, Vittorio; Greco, Dario (Elsevier BV, 2018)
      New strategies to characterize the effects of engineered nanomaterials (ENMs) based on omics technologies are emerging. However, given the intricate interplay of multiple regulatory layers, the study of a single molecular ...
    • Multi-Target Approach for Drug Discovery against Schizophrenia 

      Kondej, M; Stepnicki, P; Kaczor, AA (MDPI AGSveitsi, 2018)
      Polypharmacology is nowadays considered an increasingly crucial aspect in discovering new drugs as a number of original single-target drugs have been performing far behind expectations during the last ten years. In this ...
    • Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial 

      Rosenberg, A; Ngandu, T; Rusanen, M; Antikainen, R; Bäckman, L; Havulinna, S; Hänninen, T; Laatikainen, T; Lehtisalo, J; Levälahti, E; Lindström, J; Paajanen, T; Peltonen, M; Soininen, H; Stigsdotter-Neely, A; Strandberg, T; Tuomilehto, J; Solomon, A; Kivipelto, M (Elsevier BV, 2018)
      Introduction The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We ...
    • Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo 

      Sarin Jaakko Kalevi; Brommer Harold; Argüelles David; Puhakka Pia Henriikka; Inkinen Satu Irene; Afara Isaac Oluwaseun; Saarakkala Simo; Töyräs Juha (2017)
      Objective We investigate the potential of a prototype multimodality arthroscope, combining ultrasound, optical coherence tomography (OCT) and arthroscopic indentation device, for assessing cartilage lesions, and compare ...
    • Multimorbidity care model: Recommendations from the consensus meeting of the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS). 

      Palmer K; Marengoni A; Forjaz MJ; Jureviciene E; Laatikainen T; Mammarella F; Muth C; Navickas R; Prados-Torres A; Rijken M; Rothe U; Souchet L; Valderas J; Vontetsianos T; Zaletel J; Onder G (Elsevier BV, 2018)
      Patients with multimorbidity have complex health needs but, due to the current traditional disease-oriented approach, they face a highly fragmented form of care that leads to inefficient, ineffective, and possibly harmful ...
    • Multiplex eukaryotic transcription (in)activation : timing, bursting and cycling of a ratchet clock mechanism 

      Rybakova, Katja N.; Bruggeman, Frank J.; Tomaszewska, Aleksandra; Moné, Martijn J.; Carlberg, Carsten; Westerhoff, Hans V. (Public Library of Science (PLoS), 2015-04-24)
      Activation of eukaryotic transcription is an intricate process that relies on a multitude of regulatory proteins forming complexes on chromatin. Chromatin modifications appear to play a guiding role in protein-complex ...
    • Mutation of TP53, translocation analysis and immunohistochemical expression of MYC, BCL-2 and BCL-6 in patients with DLBCL treated with R-CHOP 

      Peroja, P; Pedersen, M; Mantere, T; Nørgaard, P; Peltonen, J; Haapasaari, KM; Böhm, J; Jantunen, E; Turpeenniemi-Hujanen, T; Rapakko, K; Karihtala, P; Soini, Y; Vasala, K; Kuittinen, O (Springer Nature America, Inc, 2018)
      Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma with diverse outcomes. Concurrent translocation of MYC and BCL-2 and/or BCL-6, and concurrent immunohistochemical (IHC) high expression of MYC and BCL-2, have ...
    • Myo- and cardiotoxic effects of the wild winter mushroom ( Flammulina velutipes) on mice 

      Mustonen, AM; Määttänen, M; Kärjä, V; Puukka, K; Aho, J; Saarela, S; Nieminen, P (SAGE Publications, 2018)
      Rhabdomyolysis (destruction of striated muscle) is a novel form of mushroom poisoning in Europe and Asia indicated by increased circulating creatine kinase levels. Particular wild fungi have also been reported to induce ...
    • NAFLD risk alleles in PNPLA3, TM6SF2, GCKR, and LYPLAL1 show divergent metabolic effects 

      Sliz, Eeva; Sebert, Sylvain; Würtz, Peter; Kangas, Antti J; Soininen, Pasi; Lehtimäki, Terho; Kähönen, Mika; Viikari, Jorma; Männikkö, Minna; Ala-Korpela, Mika; Raitakari, Olli T; Kettunen, Johannes (Oxford University Press (OUP), 2018)
    • Nanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systems 

      Laurén P; Somersalo P; Pitkänen I; Lou YR; Urtti A; Partanen J; Seppälä J; Madetoja M; Laaksonen T; Mäkitie A; Yliperttula M (Public Library of Science (PLoS), 2017)
      Hydrogel nanomaterials, especially those that are of non-human and non-animal origins, have great potential in biomedical and pharmaceutical sciences due to their versatility and inherent soft-tissue like properties. With ...
    • Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis 

      Natriuretic Peptides Studies Collaboration; Willeit P; Kaptoge S; Welsh P; Butterworth AS; Chowdhury R; Spackman SA; Pennells L; Gao P; Burgess S; Freitag DF; Sweeting M; Wood AM; Cook NR; Judd S; Trompet S; Nambi V; Olsen MH; Everett BM; Kee F et al. (Elsevier BV, 2016)
      Background Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) ...
    • Natural polyphenols as sirtuin 6 modulators 

      Rahnasto-Rilla, M; Tyni, J; Huovinen, M; Jarho, E; Kulikowicz, T; Ravichandran, S; Bohr, VA; Ferrucci, L; Lahtela-Kakkonen, M; Moaddel R (Springer Nature, 2018)
      Flavonoids are polyphenolic secondary metabolites synthesized by plants and fungus with various pharmacological effects. Due to their plethora of biological activities, they have been studied extensively in drug development. ...
    • Neuregulin signaling pathway in smoking behavior 

      Gupta R; Qaiser B; He L; Hiekkalinna TS; Zheutlin AB; Therman S; Ollikainen M; Ripatti S; Perola M; Salomaa V; Milani L; Cannon TD; Madden PAF; Korhonen T; Kaprio J; Loukola A. (Springer Nature, 2017)
      Understanding molecular processes that link comorbid traits such as addictions and mental disorders can provide novel therapeutic targets. Neuregulin signaling pathway (NSP) has previously been implicated in schizophrenia, ...
    • Neurofibromatosis type 1 is not associated with subarachnoid haemorrhage 

      Kurtelius A; Kallionpaa RA; Huttunen J; Huttunen TJ; Helin K; Koivisto T; Frosen J; zu Fraunberg MV; Peltonen S; Peltonen J; Jaaskelainen JE; Lindgren AE (Public Library of Science (PLoS), 2017)
      Background The prevalence of intracranial aneurysms (IAs) has been proposed to be elevated in the patients with neurofibromatosis type 1 (NF1). Our aims were to determine the prevalence of NF1 in a large Finnish population ...
    • Neuroimaging in animal models of epilepsy 

      Bertoglio Daniele; Verhaeghe Jeroen; Dedeurwaerdere Stefanie; Gröhn Olli (Elsevier BV, 2017)
      Epilepsy is one of the most common chronic neurological conditions worldwide. The current poor understanding and lack of reliable biomarkers of the epileptogenic process are the major limitations in the development of ...