Now showing items 763-782 of 1382

    • Lemmikkituotteisiin, koiran ulkokorvan tulehduksiin ja korvahuuhteisiin liittyvä osaaminen apteekeissa 

      Kiili, Johanna; Karttunen, Niina (, 2018)
      Johdanto: Apteekeissa myydään yleisesti lemmikkien hoitoon tarkoitettuja lääkkeitä ja vapaan kaupan tuotteita, joista on rajallisesti saatavilla tutkittua tietoa. Farmaseuttien ja proviisorien perusopintoihin Suomessa ...
      Tieteelliset aikakauslehtiartikkelit

    • Lifetime antipsychotic medication and cognitive performance in schizophrenia at age 43 years in a general population birth cohort 

      Husa AP; Moilanen J; Murray GK; Marttila R; Haapea M; Rannikko I; Barnett JH; Jones PB; Isohanni M; Remes AM; Koponen H; Miettunen J; Jääskeläinen E (© Elsevier BV, 2016)
      This naturalistic study analysed the association between cumulative lifetime antipsychotic dose and cognition in schizophrenia after an average of 16.5 years of illness. Sixty participants with schizophrenia and 191 controls ...

    • Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men 

      Suvitaival T; Bondia-Pons I; Yetukuri L; Pöhö P; Nolan JJ; Hyötyläinen T; Kuusisto J; Orešic M (Elsevier BV, 2018)
      Background There is a need for early markers to track and predict the development of type 2 diabetes mellitus (T2DM) from the state of normal glucose tolerance through prediabetes. In this study we tested whether the ...

    • Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke 

      Holmes, MV; Millwood, IY; Kartsonaki, C; Hill, MR; Bennett, DA; Boxall, R; Guo, Y; Xu, X; Bian, Z; Hu, R; Walters, RG; Chen, J; Ala-Korpela, M; Parish, S; Clarke, RJ; Peto, R; Collins, R; Li, L; Chen, Z (Elsevier BV, 2018)
      Background Blood lipids are established risk factors for myocardial infarction (MI), but uncertainty persists about the relevance of lipids, lipoprotein particles, and circulating metabolites for MI and stroke ...
      Tieteelliset aikakauslehtiartikkelit

    • Lipoprotein(a) is not associated with venous thromboembolism risk 

      Kunutsor, SK; Mäkikallio, TH; Kauhanen, J; Voutilainen, A; Laukkanen, JA (Informa UK Limited, 2019)
      Objectives. Evidence from case-control studies as well as meta-analyses of these study designs suggest elevated lipoprotein(a) [Lp(a)] to be associated with an increased risk of venous thromboembolism (VTE). Prospective ...
      Tieteelliset aikakauslehtiartikkelit

    • Liver enzymes in alcohol consumers with or without binge drinking 

      Nivukoski, U; Bloigu, A; Bloigu, R; Aalto, M; Laatikainen, T; Niemelä, O (Elsevier BV, 2019)
      Background While alcohol use is linked with a wide variety of health problems, the question of whether differences in drinking patterns could yield different outcomes has remained unclear. Patients and methods We ...
      Tieteelliset aikakauslehtiartikkelit

    • Local adventitial anti-angiogenic gene therapy reduces growth of vasa-vasorum and in-stent restenosis in WHHL rabbits 

      Hytönen, Jarkko P; Taavitsainen, Jouni; Laitinen, Johannes T T; Partanen, Anna; Alitalo, Kari; Leppänen, Olli; Ylä-Herttuala, Seppo (Elsevier BV, 2018)
      Background Antiproliferative drugs in drug eluting stents (DES) are associated with complications due to impaired re-endothelialization. Additionally, adventitial neovascularization has been suggested to contribute to ...
      Tieteelliset aikakauslehtiartikkelit

    • Long Non-Coding RNA Modulation of VEGF-A during Hypoxia 

      Nieminen, T; Scott, TA; Lin, FM; Chen, Z; Yla-Herttuala, S; Morris, KV (MDPI AG, 2018)
      The role and function of long non-coding RNAs (lncRNAs) in modulating gene expression is becoming apparent. Vascular endothelial growth factor A (VEGF-A) is a key regulator of blood vessel formation and maintenance making ...
      Tieteelliset aikakauslehtiartikkelit

    • Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study 

      Huhtaniska S; Jääskeläinen E; Heikka T. Moilanen JS; Lehtiniemi H; Tohka J; Manjón JV; Coupé P; Björnholm L; Koponen H; Veijola J; Isohanni M; Kiviniemi V; Murray GK; Miettunen J (Elsevier BV, 2017)
      High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting ...

    • Long-term effects of functional impairment on fracture risk and mortality in postmenopausal women 

      Rikkonen, T; Poole, K; Sirola, J: Sund, R; Honkanen, R; Kröger, H (Springer Nature, 2018)
      Summary Our findings imply that simple functional tests can predict both hip fracture risk and excess mortality in postmenopausal women. Since the tests characterize general functional capacity (one-legged stance, squatting ...
      Tieteelliset aikakauslehtiartikkelit

    • Long-term exercise protects against cellular stresses in aged mice 

      Belaya, Irina; Suwa, Masataka; Chen, Tao; Giniatullin, Rashid; Kanninen, Katja; Atalay, Mustafa; Kumagai, Shuzo (Hindawi Limited, 2018)
      The current study examined the effect of aging and long-term wheel-running on the expression of heat shock protein (HSP), redox regulation, and endoplasmic reticulum (ER) stress markers in tibialis anterior (T.A.) and ...
      Tieteelliset aikakauslehtiartikkelit

    • Long-Term Increase of Radiographic Damage and Disability in Patients with RA in Relation to Disease Duration in the Era of Biologics. Results from the SCQM Cohort 

      Heinimann K; von Kempis J; Sauter R; Schiff M; Sokka-Isler T; Schulze-Koops H; Müller R. (MDPI AG, 2018)
      Objectives: There is little information on the relation between disease duration, disability and radiographic outcome since the introduction of biologics into the therapy of rheumatoid arthritis (RA). No long -term cohort ...
      Tieteelliset aikakauslehtiartikkelit

    • Long-term outcome of refractory status epilepticus in adults: A retrospective population-based study 

      Kantanen A-M; Reinikainen M; Parviainen I; Kälviäinen R (Elsevier BV, 2017)
      Purpose Refractory status epilepticus (RSE) is a neurological emergency with significant morbidity and mortality. We aimed to analyze the long-term outcome of intensive care unit (ICU)-treated RSE and super-refractory ...

    • Long-term prognosis of chronic cough : a prospective, observational cohort study 

      Koskela Heikki O; Lätti Anne M; Purokivi Minna K (Springer Nature, 2017)
      Background The long-term prognosis of chronic cough and its determinants need to be clarified. Methods This is a prospective, observational cohort study. Eighty-nine unselected subjects with chronic (> 8 weeks’ duration) ...

    • Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea 

      Hietakoste, Salla; Korkalainen, Henri; Kainulainen, Samu; Sillanmäki, Saara; Nikkonen, Sami; Myllymaa, Sami; Duce, Brett; Töyräs, Juha; Leppänen, Timo (Springer Science and Business Media LLC, 2020)
      Low long-term heart rate variability (HRV), often observed in obstructive sleep apnea (OSA) patients, is a known risk factor for cardiovascular diseases. However, it is unclear how the type or duration of individual ...
      Tieteelliset aikakauslehtiartikkelit

    • Longitudinal Associations of Fitness, Motor Competence, and Adiposity with Cognition 

      Haapala, Eero A; Lintu, Niina; Väistö, Juuso; Tompuri, Tuomo; Soininen, Sonja; Viitasalo, Anna; Eloranta, Aino-Maija; Venäläinen, Taisa; Sääkslahti, Arja; Laitinen, Tomi; Lakka, Timo A (Ovid Technologies (Wolters Kluwer Health), 2019)
      Purpose The purpose of this study was to investigate the longitudinal associations of cardiorespiratory fitness (CRF), motor competence (MC), and body fat percentage (BF%) with cognition in children. Methods Altogether, ...
      Tieteelliset aikakauslehtiartikkelit

    • Longitudinal associations of physical activity and sedentary time with cardiometabolic risk factors in children 

      Väistö, Juuso; Haapala, Eero A; Viitasalo, Anna; Schnurr, Theresia M; Kilpeläinen, Tuomas O; Karjalainen, Panu; Westgate, Kate; Lakka, Hanna-Maaria; Laaksonen, David E; Ekelund, Ulf; Brage, Søren; Lakka, Timo A (Wiley, 2019)
      Background There are few prospective studies on the associations of changes in objectively measured vigorous physical activity (VPA∆), moderate‐to‐vigorous physical activity (MVPA∆), light physical activity (LPA∆), and ...
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    • Longitudinal associations of sauna bathing with inflammation and oxidative stress: The KIHD prospective cohort study 

      Kunutsor, Setor K; Laukkanen, Tanjaniina; Laukkanen, Jari A (Informa UK Limited, 2018)
      Purpose: We sought to determine cross-sectional and longitudinal associations of frequency of sauna bathing with high sensitivity C-reactive protein (hsCRP), fibrinogen, leucocyte count and gamma-glutamyltransferase ...
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    • Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder 

      Savchenko E; Singh Y; Konttinen H; Lejavova K; Mediavilla Santos L; Grubman A; Kärkkäinen V; Keksa-Goldsteine V; Naumenko N; Tavi P; White AR; Malm TM; Koistinaho J; Kanninen KM (2017)
      Neural stem/progenitor cells (NPCs) generate new neurons in the brain throughout an individual's lifetime in an intricate process called neurogenesis. Neurogenic alterations are a common feature of several adult-onset ...

    • Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice 

      Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T (Oxford University Press (OUP), 2019)
      The Finnish-variant late infantile neuronal ceroid lipofuscinosis, also known as CLN5 disease, is caused by mutations in the CLN5 gene. Cln5 is strongly expressed in the developing brain and expression continues into ...
      Tieteelliset aikakauslehtiartikkelit