Now showing items 21-40 of 1052

    • The Nordic diet and cognition – The DR's EXTRA Study 

      Männikkö, Reija; Komulainen, Pirjo; Schwab, Ursula; Heikkilä, Harri M.; Savonen, Kai; Hassinen, Maija; Hänninen, Tuomo; Kivipelto, Miia; Rauramaa, Rainer (Cambridge University Press (CUP), 2015-06-24)
      The rapid increase in the prevalence of dementia associated with ageing populations has stimulated interest in identifying modifiable lifestyle factors that could prevent cognitive impairment. One such potential preventive ...
    • Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies 

      Moilanen, Anu-Maarit; Riikonen, Reetta; Oksala, Riikka; Ravanti, Laura; Aho, Eija; Wohlfahrt, Gerd; Nykänen, Pirjo S; Törmäkangas, Olli P; Palvimo, Jorma J; Kallio, Pekka J (Nature Publishing Group, 2015-07-03)
      Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR, and several mechanisms have been proposed to explain ...
    • Global SUMOylation on active chromatin is an acute heat stress response restricting transcription 

      Niskanen, Einari A.; Malinen, Marjo; Sutinen, Päivi; Toropainen, Sari; Paakinaho, Ville; Vihervaara, Anniina; Joutsen, Jenny; Kaikkonen, Minna U.; Sistonen, Lea; Palvimo, Jorma J. (BioMed Central, 2015-07-28)
      Background Cells have developed many ways to cope with external stress. One distinctive feature in acute proteotoxic stresses, such as heat shock (HS), is rapid post-translational modification of proteins by SUMOs (small ...
    • Dark chocolate and reduced snack consumption in mildly hypertensive adults: an intervention study 

      Koli, Raika; Köhler, Klaus; Tonteri, Elina; Peltonen, Juha; Tikkanen, Heikki; Fogelholm, Mikael (BioMed Central, 2015-08-22)
      Background Several studies have shown that cocoa and cocoa-containing foods have the potential to lower blood pressure and improve endothelial function. Most of the studies reporting the beneficial effects of dark chocolate ...
    • Reorganization of Nuclear Pore Complexes and the Lamina in Late-Stage Parvovirus Infection 

      Mäntylä, Elina; Niskanen, Einari A.; Ihalainen, Teemu O.; Vihinen-Ranta, Maija (American Society for Microbiology, 2015-08-26)
      Canine parvovirus (CPV) infection induces reorganization of nuclear structures. Our studies indicated that late-stage infection induces accumulation of nuclear pore complexes (NPCs) and lamin B1 concomitantly with a decrease ...
    • Diagnosis of Knee Osteochondral Lesions With Ultrasound 

      Penttilä, Pekko; Liukkonen, Jukka; Joukainen, Antti; Virén, Tuomas; Jurvelin, Jukka S; Töyräs, Juha; Kröger, Heikki (Elsevier BV, 2015-09-14)
      Evaluation of articular cartilage and subchondral bone is essential in the diagnosis of joint diseases and injuries. Interobserver and intraobserver reproducibilities of arthroscopic grading are only poor to moderate. Thus, ...
    • Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase 

      Navia-Paldanius, Dina; Aaltonen, Niina; Lehtonen, Marko; Savinainen, Juha R.; Taschler, Ulrike; Radner, Franz P.W.; Zimmermann, Robert; Laitinen, Jarmo T. (Elsevier BV, 2015-09-18)
      In mammalian brain, monoacylglycerol lipase (MAGL) is the primary enzyme responsible for terminating signaling function of the endocannabinoid 2-arachidonoylglycerol (2-AG). Previous in vivo studies with mice indicate that ...
    • Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia 

      Koistinen, Ville; Kärnä, Riikka; Koistinen, Arto; Arjonen, Antti; Tammi, Markku; Rilla, Kirsi (Elsevier BV, 2015-10-01)
      Previous studies have shown that overexpression of enzymatically active GFP-HAS induces the growth of long, slender protrusions that share many features of both filopodia and microvilli. These protrusions are dependent on ...
    • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 

      Winkler, Thomas W; Justice, Anne E; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F; Chu, Su; Czajkowski, Jacek; Esko, Tõnu; Fall, Tove; Yaluri, Alena (Public Library of Science (PLoS), 2015-10-01)
      Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and ...
    • Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network 

      Heinäniemi, Merja Hannele; Maria Pires Pacheco; Elisabeth John; Tony Kaoma; Nathalie Nicot; Laurent Vallar; Jean-Luc Bueb; Lasse Sinkkonen; Thomas Sauter (BioMed Central, 2015-10-19)
      Background The reconstruction of context-specific metabolic models from easily and reliably measurable features such as transcriptomics data will be increasingly important in research and medicine. Current reconstruction ...
    • SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling 

      Yan, Yan; Ollila, Saara; Wong, Iris P. L.; Vallenius, Tea; Palvimo, Jorma J.; Vaahtomeri, Kari; Mäkelä, Tomi P. (Nature Publishing Group, 2015-10-23)
      AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate specificity would be useful to understand its role in particular cellular ...
    • Epigenome-wide effects of vitamin D and their impact on the transcriptome of human monocytes involve CTCF 

      Seuter, Sabine; Neme, Antonio; Carlberg, Carsten (Oxford University Press on behalf of Nucleic Acids Research., 2015-12-28)
      The physiological functions of vitamin D are mediated by its metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) activating the transcription factor vitamin D receptor (VDR). In THP-1 human monocytes we demonstrated ...
    • Variable course of disease of rheumatoid arthritis-associated usual interstitial pneumonia compared to other subtypes 

      Nurmi Hanna M; Purokivi Minna K; Kärkkäinen Miia S; Kettunen Hannu-Pekka; Selander Tuomas A; Kaarteenaho Riitta L (Springer Nature, 2016)
      Background In rheumatoid arthritis-associated interstitial lung disease (RA-ILD), occurring in 10 % of patients with patients with RA, usual interstitial pattern (UIP) has shown to associate with poor prognosis but more ...
    • Rey's Auditory Verbal Learning Test scores can be predicted from whole brain MRI in Alzheimer's disease 

      Moradi E; Hallikainen I; Hänninen T; Tohka J (Elsevier BV, 2016)
      Rey’s Auditory Verbal Learning Test (RAVLT) is a powerful neuropsychological tool for testing episodic memory, which is widely used for the cognitive assessment in dementia and pre-dementia conditions. Several studies have ...
    • Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology 

      Dourlen P; Fernandez-Gomez FJ; Dupont C; Grenier-Boley B; Bellenguez C; Obriot H; Caillierez R; Sottejeau Y; Chapuis J; Bretteville A; Abdelfettah F; Delay C; Malmanche N; Soininen H; Hiltunen M; Galas MC; Amouyel P; Sergeant N; Buée L; Lambert JC; Dermaut B (Springer Nature, 2016)
      A recent genome-wide association meta-analysis for Alzheimer’s disease (AD) identified 19 risk loci (in addition to APOE) in which the functional genes are unknown. Using Drosophila, we screened 296 constructs targeting ...
    • Newtonian and Lagrangian Mechanics of a Production System 

      Estola Matti; Dannenberg Alia Asha (Hyperion University, 2016)
      We define the economic correspondents for kinetic and potential energy of production and mutually coherent Newtonian and Lagrangian frameworks for modeling production. The neoclassical theory is shown to correspond to ...
    • Winter is coming: nightmares and sleep problems during seasonal affective disorder 

      Sandman Nils; Merikanto Ilona; Määttänen Hanna; Valli Katja; Kronholm Erkki; Laatikainen Tiina; Partonen Timo; Paunio Tiina (Wiley-Blackwell, 2016)
      Sleep problems, especially nightmares and insomnia, often accompany depression. This study investigated how nightmares, symptoms of insomnia, chronotype and sleep duration associate with seasonal affective disorder, a ...
    • Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis 

      Natriuretic Peptides Studies Collaboration; Willeit P; Kaptoge S; Welsh P; Butterworth AS; Chowdhury R; Spackman SA; Pennells L; Gao P; Burgess S; Freitag DF; Sweeting M; Wood AM; Cook NR; Judd S; Trompet S; Nambi V; Olsen MH; Everett BM; Kee F et al. (Elsevier BV, 2016)
      Background Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) ...
    • Career anchors of dentist leaders 

      Tuononen Tiina; Lammintakanen Johanna; Suominen Anna Liisa (Informa UK Limited, 2016)
      Objective: The work of a health care leader is demanding; in order to cope, leaders need motivation and support. The occurrence of intrinsic factors called career anchors (combination of one’s competence, motives and values) ...
    • Development of a fermented quinoa-based beverage 

      Ludena Urquizo Fanny Emma; García Torres Silvia Melissa; Tolonen Tiina; Jaakkola Mari; Grazzia Pena-Niebuhr Maria; von Wright Atte; Repo-Carrasco-Valencia Ritva; Korhonen Hannu; Plumed-Ferrer Carme (Wiley-Blackwell, 2016)
      Quinoa is a crop that originated from the Andes. It has high nutritional value, outstanding agro-ecological adaptability, and low water requirements. Quinoa is an excellent crop alternative to help overcome food shortages, ...