Browsing Terveystieteiden tiedekunta by Author "A.I. Virtanen -instituutti / Neurobiologia"

Now showing items 1-9 of 9

    • Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-ß 

      Gureviciene Irina; Gurevicius Kestutis; Mugantseva Ekaterina; Kislin Mikhail; Khiroug Leonard; Tanila Heikki (IOS Press, 2017)
      Amyloid plaques, although inducing damage to the immediately surrounding neuropil, have been proposed to provide a relatively innocuous way to deposit toxic soluble amyloid-β (Aβ) species. Here we address this hypothesis ...
      Tieteelliset aikakauslehtiartikkelit

    • Chronic MeHg exposure modifies the histone H3K4me3 epigenetic landscape in Caenorhabditis elegans 

      Rudgalvyte Martina; Peltonen Juhani; Lakso Merja; Wong Garry (Elsevier BV, 2017)
      Methylmercury (MeHg) is a persistent environmental pollutant that occurs in the food chain, at occupational sites, and via medical procedures. Exposure in humans and animal models results in renal, neuro, and reproductive ...
      info:eu-repo/semantics/article

    • Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors 

      von Ossowski L; Li LL; Möykkynen T; Coleman SK; Courtney MJ; Keinänen K (Public Library of Science (PLoS), 2017)
      Recent studies indicate that glutamatergic signaling involves, and is regulated by, thiol modifying and redox-active compounds. In this study, we examined the role of a reactive cysteine residue, Cys-893, in the cytosolic ...
      info:eu-repo/semantics/article

    • Efficient binding of the NOS1AP C-terminus to the nNOS PDZ pocket requires the concerted action of the PDZ ligand motif, the internal ExF site and structural integrity of an independent element 

      Li L-L; Cisek K; Courtney MJ (Frontiers Media SA, 2017)
      Neuronal nitric oxide synthase is widely regarded as an important contributor to a number of disorders of excitable tissues. Recently the adaptor protein NOS1AP has emerged as a contributor to several nNOS-linked conditions. ...
      info:eu-repo/semantics/article

    • Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice 

      Jin, Nanxiang; Lipponen, Arto; Koivisto, Hennariikka; Gurevicius, Kestutis; Tanila, Heikki (Elsevier BV, 2018)
      Amyloid plaque–forming transgenic mice display neuronal hyperexcitability, epilepsy, and sudden deaths in early adulthood. However, it is unknown whether hyperexcitability persists until middle ages when memory impairment ...
      Tieteelliset aikakauslehtiartikkelit

    • Lack of collagen XV is protective after ischemic stroke in mice 

      Dhungana Hiramani; Huuskonen Mikko T; Pihlajaniemi Taina; Heljasvaara Ritva; Vivien Denis; Kanninen Katja M; Malm Tarja; Koistinaho Jari; Lemarchant Sighild (Springer Nature, 2017)
      Collagens are key structural components of basement membranes, providing a scaffold for other components or adhering cells. Collagens and collagen-derived active fragments contribute to biological activities such as cell ...
      info:eu-repo/semantics/article

    • Quantitative susceptibility mapping of the rat brain after traumatic brain injury 

      Chary, Karthik; Nissi, Mikko J; Nykänen, Olli; Manninen, Eppu; Rey, Ramón I; Shmueli, Karin; Sierra, Alejandra; Gröhn, Olli (Wiley, 2021)
      The primary lesion arising from the initial insult after traumatic brain injury (TBI) triggers a cascade of secondary tissue damage, which may also progress to connected brain areas in the chronic phase. The aim of this ...
      Tieteelliset aikakauslehtiartikkelit

    • Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy 

      Leinonen Henri; Keksa-Goldsteine Velta; Ragauskas Symantas; Kohlmann Philip; Signh Yajuvinder; Savchencko Ekaterina; Puranen Jooseppi; Malm Tarja; Kalesnykas Giedrius; Koistinaho Jari; Tanila Heikki; Kanninen Katja M (Springer Nature, 2017)
      The Finnish variant of late infantile neuronal ceroid lipofuscinosis (CLN5 disease) belongs to a family of neuronal ceroid lipofuscinosis (NCLs) diseases. Vision loss is among the first clinical signs in childhood forms ...
      info:eu-repo/semantics/article

    • A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs 

      Melero-Fernandez de Mera Raquel M; Li Li-Li; Popinigis Arkadiusz; Cisek Katryna; Tuittila Minna; Yadav Leena; Serva Andrius; Courtney Michael J (Springer Nature, 2017)
      Engineering light-sensitive protein regulators has been a tremendous multidisciplinary challenge. Optogenetic regulators of MAPKs, central nodes of cellular regulation, have not previously been described. Here we present ...
      info:eu-repo/semantics/article