Browsing Terveystieteiden tiedekunta by Author "Bahrpeyma, Sina"
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Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling
Bahrpeyma, Sina; Reinisalo, Mika; Hellinen, Laura; Auriola, Seppo; del Amo, Eva M; Urtti, Arto (Elsevier B.V, 2022)Melanin binding of drugs is known to increase drug concentrations and retention in pigmented eye tissues. Even though the correlation between melanin binding in vitro and exposure to pigmented eye in vivo has been shown, ...
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Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs
Hellinen, Laura; Bahrpeyma, Sina; Rimpelä, Anna-Kaisa; Hagström, Marja; Reinisalo, Mika; Urtti, Arto (MDPI AG, 2020)Interactions between drugs and melanin pigment may have major impacts on pharmacokinetics. Therefore, melanin binding can modify the efficacy and toxicity of medications in ophthalmic and other disease of pigmented tissues, ...Tieteelliset aikakauslehtiartikkelit
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Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery
Bhattacharya, Madhushree; Sadeghi, Amir; Sarkhel, Sanjay; Hagström, Marja; Bahrpeyma, Sina; Toropainen, Elisa; Auriola, Seppo; Urtti, Arto (Elsevier BV, 2020)Tissue barriers limit drug delivery in the eye. Therefore, retinal diseases are treated with intravitreal injections. Delivery systems with reduced dosing frequency and/or cellular drug delivery properties are needed. We ...Tieteelliset aikakauslehtiartikkelit