Browsing Terveystieteiden tiedekunta by Subject "Cancer genetics"
Now showing items 1-3 of 3
Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility (Springer Nature, 2017)Several known breast cancer susceptibility genes encode proteins involved in DNA damage response (DDR) and are characterized by rare loss-of-function mutations. However, these explain less than half of the familial cases. ...info:eu-repo/semantics/article
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus (Springer Nature, 2016)A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify ...Tieteelliset aikakauslehtiartikkelit
Uptake of genetic testing by the children of Lynch syndrome variant carriers across three generations (Springer Nature, 2017)Many Lynch syndrome (LS) carriers remain unidentified, thus missing early cancer detection and prevention opportunities. Tested probands should inform their relatives about cancer risk and options for genetic counselling ...info:eu-repo/semantics/article