Now showing items 1-6 of 6

    • Changes in intestinal immunity, gut microbiota, and expression of energy metabolism-related genes explain adenoma growth in bilberry and cloudberry-fed ApcMin mice 

      Päivärinta Essi; Niku Mikael; Maukonen Johanna; Storvik Markus; Heiman-Lindh Anu; Saarela Maria; Pajari Anne-Maria; Mutanen Marja (Elsevier BV, 2016-10-15)
      We showed previously that ellagitannin-rich cloudberries and anthocyanin-rich bilberries reduce the number of intestinal adenomas in multiple intestinal neoplasia/+ (ApcMin) mice. We also found that cloudberries decreased ...
    • Large meta-analysis of genome-wide association studies identifies five loci for lean body mass 

      Zillikens M Carola; Demissie Serkalem; Hsu Yi-Hsiang; Yerges-Armstrong Laura M; Chou Wen-Chi; Stolk Lisette; Livshits Gregory; Broer Linda; Johnson Toby; Koller Daniel L; Kutalik Zoltán; Luan Jian'an; Malkin Ida; Ried Janina S; Smith Albert V; Thorleifsson Gudmar; Vandenput Liesbeth; Zhao Jing Hua; Zhang Weihua; Aghdassi Ali et al. (incl. Cederberg Henna) (Springer Nature, 2017)
      Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and ...
    • Mitochondrial genes are altered in blood early in Alzheimer's disease 

      Lunnon K; Keohane A; Pidsley R; Newhouse S; Riddoch-Contreras J; Thubron EB; Devall M; Soininen H; Kloszewska I; Mecocci P; Tsolaki M; Vellas B; Schalkwyk L; Dobson R; Malik AN; Powell J; Lovestone S; Hodges A (Elsevier BVYhdysvallat (USA), 2017)
      Although mitochondrial dysfunction is a consistent feature of Alzheimer's disease in the brain and blood, the molecular mechanisms behind these phenomena are unknown. Here we have replicated our previous findings demonstrating ...
    • Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses 

      Aho, Vilma; Ollila, Hanna M; Kronholm, Erkki; Bondia-Pons, Isabel; Soininen, Pasi; Kangas, Antti J; Hilvo, Mika; Seppälä, Ilkka; Kettunen, Johannes; Oikonen, Mervi; Raitoharju, Emma; Hyötyläinen, Tuulia; Kähönen, Mika; Viikari, Jorma S; Härmä, Mikko; Sallinen, Mikael; Olkkonen, Vesa M; Alenius, Harri; Jauhiainen, Matti; Paunio, Tiina et al (Nature Publishing Group, 2016)
      Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were addressed using two approaches: an experimental, ...
    • Relevance of Vitamin D Receptor Target Genes for Monitoring the Vitamin D Responsiveness of Primary Human Cells 

      Vukić, Maja; Neme, Antonio; Seuter, Sabine; Saksa, Noora; de Mello, Vanessa D. F.; Nurmi, Tarja; Uusitupa, Matti; Tuomainen, Tomi-Pekka (Public Library of Science (PLoS), 2015-04-13)
      Vitamin D3 has transcriptome- and genome-wide effects and activates, via the binding of its metabolite 1α,25-dihydroxyvitamin D3 to the transcription factor vitamin D receptor (VDR), several hundred target genes. Using ...
    • Translation, but not transfection limits clinically relevant, exogenous mRNA based induction of alpha-4 integrin expression on human mesenchymal stem cells 

      Nowakowski A; Andrzejewska A; Boltze J; Nitzsche F; Cui LL; Jolkkonen J; Walczak P; Lukomska B; Janowski M (Springer Nature, 2017)
      Mesenchymal stem cells (MSCs) represent promising resource of cells for regenerative medicine in neurological disorders. However, efficient and minimally invasive methods of MSCs delivery to the brain still have to be ...