Now showing items 1-8 of 8

    • Activation of immunosuppressive network in the aging process 

      Salminen, Antero (Elsevier BV, 2020)
      Chronic low-grade inflammation has a key role in the aging process, a state called inflammaging. It is known that the chronic inflammatory condition generates counteracting immunosuppressive state in many diseases. ...
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    • Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells 

      Singha, Prosanta; Mäklin, Kiira; Vihavainen, Taina; Laitinen, Tuomo; Nevalainen, Tapio; Patil, Mahadeo; Tonduru, Arun; Poso, Antti; Laitinen, Jarmo; Savinainen, Juha (Elsevier BV, 2020)
      De novo synthesis of fatty acids is essential to maintain intensive proliferation of cancer cells. Unlike normal cells that utilize food-derived circulating lipids for their fuel, cancer cells rely on heightened lipogenesis ...
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    • Extracellular vesicles are integral and functional components of the extracellular matrix 

      Rilla, Kirsi; Mustonen, Anne-Mari; Thanigai, Arasu Uma; Härkönen, Kai; Matilainen, Johanna; Nieminen, Petteri (Elsevier BV, 2019)
      Extracellular vesicles (EV) are small plasma membrane-derived particles released into the extracellular space by virtually all cell types. Recently, EV have received increased interest because of their capability to carry ...
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    • Hyaluronan synthase 1 : a mysterious enzyme with unexpected functions 

      Siiskonen, Hanna; Oikari, Sanna; Pasonen-Seppänen, Sanna; Rilla, Kirsi (Frontiers Media SA, 2015)
      Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the ...

    • Integrated drug profiling and CRISPR screening identify essential pathways for CAR T cell cytotoxicity 

      Dufva, O; Koski, J; Maliniemi, P; Ianevski, A; Klievink, J; Leitner, J; Pölönen, P; Hohtari, H; Saeed, K; Hannunen, T; Ellonen, P; Steinberger, P; Kankainen, M; Aittokallio, T; Keränen, MAI; Korhonen, M; Mustjoki, S (American Society of Hematology, 2020)
      Chimeric antigen receptor (CAR) T-cell therapy has proven effective in relapsed and refractory B-cell malignancies, but resistance and relapses still occur. Better understanding of mechanisms influencing CAR T-cell ...
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    • Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration 

      Katisko, Kasper; Haapasalo, Annakaisa; Koivisto, Anne; Kruger, Johanna; Hartikainen, Päivi; Korhonen, Ville; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino (, 2018)
      Several studies have reported reduced risk of cancer in patients with Alzheimer’s disease (AD) or Parkinson’s disease. The relationship between cancer and frontotemporal lobar degeneration (FTLD) has not been previously ...
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    • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes 

      Mavaddat, N; Michailidou, K; Dennis, J; Lush, M; Fachal, L; Lee, A; Tyrer, JP; Chen, TH; Wang, Q; Bolla, MK; Yang, X; Adank, MA; Ahearn, T; Aittomäki, K; Allen, J; Andrulis, IL; Anton-Culver, H; Antonenkova, NN; Arndt, V; Aronson KJ; et al. [Incl Auvinen, Päivi; Kataja, Vesa; Kosma, Veli-Matti; Mannermaa, Arto] (Elsevier BV, 2019)
      Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen ...
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    • Serum n-6 polyunsaturated fatty acids and risk of death: the Kuopio Ischaemic Heart Disease Risk Factor Study 

      Virtanen, Jyrki K; Wu, Jason HY; Voutilainen, Sari; Mursu, Jaakko; Tuomainen, Tomi-Pekka (Oxford University Press (OUP), 2018)
      Background The cardioprotective properties of linoleic acid (LA), a major n–6 (ω-6) polyunsaturated fatty acid (PUFA), have been recognized, but less is known about its associations with other causes of death. Relatively ...
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