Now showing items 1-5 of 5

    • Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial Infarction 

      Kaikkonen Minna U; Halonen Paavo; Liu Oscar Hsin-Fu; Turunen Tiia A; Pajula Juho; Moreau Pierre; Selvarajan Ilakya; Tuomainen Tomi; Aavik Einari; Tavi Pasi; Ylä-Herttuala Seppo (Ovid Technologies (Wolters Kluwer Health), 2017)
      Background Microarrays and RNA sequencing are widely used to profile transcriptome remodeling during myocardial ischemia. However, the steady-state RNA analysis lacks in sensitivity to detect all noncoding RNA species and ...
    • Melatonin receptor type 1A gene linked to Alzheimer's disease in old age 

      Sulkava, S; Muggalla, P; Sulkava, R; Ollila, HM; Peuralinna, T; Myllykangas, L; Kaivola, K; Stone, DJ; Traynor, BJ; Renton, AE; Rivera, AM; Helisalmi, S; Soininen, H; Polvikoski , T; Hiltunen, M; Tienari, PJ; Huttunen, HJ; Paunio, T (Oxford University Press (OUP)Yhdysvallat (USA), 2018)
      Disruption of the circadian rhythms is a frequent preclinical and clinical manifestation of Alzheimer’s disease. Furthermore, it has been suggested that shift work is a risk factor for Alzheimer’s disease. Previously, we ...
    • Recent advances in novel therapies for lipid disorders 

      Tirronen, Annakaisa; Hokkanen, Krista; Vuorio, Taina; Ylä-Herttuala, Seppo (Oxford University Press (OUP), 2019)
      The prevalence of lipid disorders is alarmingly increasing in the Western world. They are the result of either primary causes, such as unhealthy lifestyle choices or inherited risk factors, or secondary causes like other ...
    • Sarcoplasmic reticulum Ca2+ -induced Ca2+ release regulates class IIa HDAC localization in mouse embryonic cardiomyocytes 

      Karppinen, Sari; Hänninen, Sandra L; Rapila, Risto; Tavi, Pasi (Wiley-Blackwell, 2018)
      In embryonic cardiomyocytes, sarcoplasmic reticulum (SR)‐derived Ca2+ release is required to induce Ca2+ oscillations for contraction and to control cardiac development through Ca2+‐activated pathways. Here, our aim was ...
    • Supervised pathway analysis of blood gene expression profiles in Alzheimer's disease 

      Moradi, E; Marttinen, M; Häkkinen, T; Hiltunen, M; Nykter, M (Elsevier BVYhdysvallat (USA), 2019)
      Early identification and treatment of Alzheimer's disease (AD) is hampered by the lack of easily accessible biomarkers. Currently available fluid biomarkers of AD provide indications of the disease stage; however, these ...