Browsing Terveystieteiden tiedekunta by Subject "genetics"

Now showing items 1-11 of 11

    • A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity 

      Bradfield, Jonathan P; Vogelezang, Suzanne; Felix, Janine F; Chesi, Alessandra; Helgeland, Øyvind; Horikoshi, Momoko; Karhunen, Ville; Lowry, Estelle; Cousminer, Diana L; Ahluwalia, Tarunveer S; Thiering, Elisabeth; Boh, Eileen Tai-Hui; Zafarmand, Mohammad H; Vilor-Tejedor, Natalia; Wang, Carol A; Joro, Raimo; Chen, Zhanghua; Gauderman, William J; Pitkänen, Niina; Parra, Esteban J; et al. (incl. Atalay, Mustafa; Lakka, Timo A; Lindi, Virpi) (Oxford University Press (OUP), 2019)
      Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted ...
      Tieteelliset aikakauslehtiartikkelit

    • Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus 

      Huovinen J; Helisalmi S; Paananen J; Laiterä T; Kojoukhova M; Sutela A; Vanninen R; Laitinen M; Rauramaa T; Koivisto AM; Remes AM; Soininen H; Kurki M; Haapasalo A; Jääskeläinen JE; Hiltunen M; Leinonen V (IOS Press, 2017)
      Background: Idiopathic normal pressure hydrocephalus (iNPH) is a late onset, surgically treated progressive brain disease caused by impaired cerebrospinal fluid dynamics and subsequent ventriculomegaly. Comorbid Alzheimer’s ...
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    • Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping 

      Belloy, Michael E.; Eger, Sarah J.; Le Guen, Yann; Damotte, Vincent; Ahmad, Shahzad; Ikram, M. Arfan; Ramirez, Alfredo; Tsolaki, Anthoula C.; Rossi, Giacomina; Jansen, Iris E.; de Rojas, Itziar; Parveen, Kayenat; Sleegers, Kristel; Ingelsson, Martin; Hiltunen, Mikko; Amin, Najaf; Andreassen, Ole; Sánchez-Juan, Pascual; Kehoe, Patrick; Amouyel, Philippe; Sims, Rebecca; Frikke-Schmidt, Ruth; van der Flier, Wiesje M.; Lambert, Jean-Charles; He, Zihuai; Han, Summer S.; Napolioni, Valerio; Greicius, Michael D.; for the European Alzheimer & Dementia BioBank (EADB) (BioMed Central Ltd, 2022)
      Background Genetic variants within the APOE locus may modulate Alzheimer’s disease (AD) risk independently or in conjunction with APOE*2/3/4 genotypes. Identifying such variants and mechanisms would importantly advance ...

    • Consortium genome-wide meta-analysis for childhood dental caries traits 

      Haworth, S; Shungin, D; van der Tas, JT; Vucic, S; Medina-Gomez, C; Yakimov, V; Feenstra, B; Shaffer, JR; Lee, MK; Standl, M; Thiering, E; Wang, C; Bønnelykke, K; Waage, J; Eyrich Jessen, L; Nørrisgaard, PE; Joro, R; Seppälä, I; Raitakari, O; Dudding, T; et al [Incl Lakka, T; Eloranta, A-M; Vierola, A] (Oxford University Press (OUP), 2018)
      Prior studies suggest dental caries traits in children and adolescents are partially heritable, but there has been no large-scale consortium genome-wide association study (GWAS) to date. We therefore performed GWAS for ...
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    • Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept 

      Franke, B; Stein, JL; Ripke, S; Anttila, V; Hibar, DP; van Hulzen, KJ; Arias-Vasquez, A; Smoller, JW; Nichols, TE; Neale, MC; McIntosh, AM; Lee, P; McMahon, FJ; Meyer-Lindenberg, A; Mattheisen, M; Andreassen, OA; Gruber, O; Sachdev, PS; Roiz-Santiañez, R; Saykin, AJ et al (Nature Publishing Group, 2016)
      Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are ...
      info:eu-repo/semantics/article

    • Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease 

      Peloso, GM; van der Lee, SJ; International Genomics of Alzheimer's Project (IGAP); Destefano, AL; Seshardi, S; et al. (incl. Hiltunen, Mikko; Haapasalo, Annakaisa; Helisalmi, Seppo; Koivisto, Anne) (Elsevier BV, 2018)
      Introduction There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) ...
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    • Low childhood high density lipoprotein cholesterol levels and subsequent risk for chronic inflammatory bowel disease 

      Voutilainen, Markku; Hutri-Kähonen, Nina; Tossavainen, Päivi; Sipponen, Taina; Pitkänen, Niina; Laitinen, Tomi; Jokinen, Eero; Ronnemaa, Tapani; Viikari, Jorma S A; Raitakari, Olli T; Juonala, Markus (Elsevier BV, 2018)
      Background and aims Several genetic and environmental risk factors have been linked to chronic inflammatory bowel disease (IBD). The incidence of IBD has significantly increased in developed countries during last decades. ...
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    • Mutation Analysis of the Genes Linked to Early Onset Alzheimer's Disease and Frontotemporal Lobar Degeneration 

      Luukkainen, L; Helisalmi, S; Kytövuori, L; Ahmasalo, R; Solje, E; Haapasalo, A; Hiltunen, M; Remes, AM; Krüger, J (IOS Press, 2019)
      A lot of effort has been done to unravel the genetics underlying early-onset Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). However, many familial early-onset dementia (EOD) cases still show an ...
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    • NAFLD risk alleles in PNPLA3, TM6SF2, GCKR, and LYPLAL1 show divergent metabolic effects 

      Sliz, Eeva; Sebert, Sylvain; Würtz, Peter; Kangas, Antti J; Soininen, Pasi; Lehtimäki, Terho; Kähönen, Mika; Viikari, Jorma; Männikkö, Minna; Ala-Korpela, Mika; Raitakari, Olli T; Kettunen, Johannes (Oxford University Press (OUP), 2018)
      Fatty liver has been associated with unfavourable metabolic changes in circulation. To provide insights in fatty liver-related metabolic deviations, we compared metabolic association profile of fatty liver versus metabolic ...
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    • Randomized controlled trial on the effectiveness of web-based Genomics Nursing Education Intervention for undergraduate nursing students: a study protocol 

      Dumo, AM; Laing, B; Lim, AG; Palaganas, E; Abad, PJ; Valdehueza, O; Palovaara, M; Saunders, H; Estola, M; Mandysova, P; Maguire, J; Ward, LD; Carlberg, C; Vehviläinen-Julkunen, K (Wiley, 2020)
      Aim To describe a randomized controlled trial protocol that will evaluate the effectiveness of two web‐based genomic nursing education interventions. Background Preparing future nurses to be competent in genetic and ...
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    • The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects 

      Middeldorp, Christel M; Felix, Janine F; Mahajan, Anubha; EArly Genetics Lifecourse Epidemiology (EAGLE) consortium; Early Growth Genetics (EGG) consortium (Incl Atalay, Mustafa; Lakka, Timo A); McCarthy, Mark I (Springer Nature, 2019)
      The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as ...
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