Browsing Terveystieteiden tiedekunta by Subject "genome-wide association study"

Now showing items 1-7 of 7

    • A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity 

      Bradfield, Jonathan P; Vogelezang, Suzanne; Felix, Janine F; Chesi, Alessandra; Helgeland, Øyvind; Horikoshi, Momoko; Karhunen, Ville; Lowry, Estelle; Cousminer, Diana L; Ahluwalia, Tarunveer S; Thiering, Elisabeth; Boh, Eileen Tai-Hui; Zafarmand, Mohammad H; Vilor-Tejedor, Natalia; Wang, Carol A; Joro, Raimo; Chen, Zhanghua; Gauderman, William J; Pitkänen, Niina; Parra, Esteban J; et al. (incl. Atalay, Mustafa; Lakka, Timo A; Lindi, Virpi) (Oxford University Press (OUP), 2019)
      Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted ...
      Tieteelliset aikakauslehtiartikkelit

    • Common Genetic Variation Near Melatonin Receptor 1A Gene Linked to Job-Related Exhaustion in Shift Workers 

      Sulkava Sonja; Ollila Hanna M; Alasaari Jukka; Puttonen Sampsa; Härmä Mikko; Viitasalo Katriina; Lahtinen Alexandra; Lindström Jaana; Toivola Auli; Sulkava Raimo; Kivimäki Mika; Vahtera Jussi; Partonen Timo; Silander Kaisa; Porkka-Heiskanen Tarja; Paunio Tiina (Oxford University Press (OUP), 2017)
      Study Objectives: Tolerance to shift work varies; only some shift workers suffer from disturbed sleep, fatigue, and job-related exhaustion. Our aim was to explore molecular genetic risk factors for intolerance to shift ...
      info:eu-repo/semantics/article

    • Consortium genome-wide meta-analysis for childhood dental caries traits 

      Haworth, S; Shungin, D; van der Tas, JT; Vucic, S; Medina-Gomez, C; Yakimov, V; Feenstra, B; Shaffer, JR; Lee, MK; Standl, M; Thiering, E; Wang, C; Bønnelykke, K; Waage, J; Eyrich Jessen, L; Nørrisgaard, PE; Joro, R; Seppälä, I; Raitakari, O; Dudding, T; et al [Incl Lakka, T; Eloranta, A-M; Vierola, A] (Oxford University Press (OUP), 2018)
      Prior studies suggest dental caries traits in children and adolescents are partially heritable, but there has been no large-scale consortium genome-wide association study (GWAS) to date. We therefore performed GWAS for ...
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    • FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells 

      Wong, Doris; Auguste, Gaelle; Lino Cardenas, Christian L; Turner, Adam W; Chen, Yixuan; Song, Yipei; Ma, Lijiang; Perry, R Noah; Aherrahrou, Redouane; Kuppusamy, Maniselvan; Yang, Chaojie; Mosquera, Jose Verdezoto; Dube, Collin J; Khan, Mohammad Daud; Palmore, Meredith; Kalra, Jaspreet; Kavousi, Maryam; Peyser, Patricia A; Matic, Ljubica; Hedin, Ulf; Manichaikul, Ani; Sonkusare, Swapnil K; Civelek, Mete; Kovacic, Jason C; Bjorkegren, Johan LM; Malhotra, Rajeev; Miller, Clint L (The American Heart Association, 2023)
      Background: Genome-wide association studies have identified hundreds of loci associated with common vascular diseases, such as coronary artery disease, myocardial infarction, and hypertension. However, the lack of mechanistic ...

    • Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes 

      Vogelezang, Suzanne; Bradfield, Jonathan P; Vogelezang, Suzanne; Bradfield, Jonathan P; Johansson, Stefan; Stergiakouli, Evie; Thiering, Elisabeth; Pennell, Craig E; Ahluwalia, Tarunveer S; Karhnen, Ville; Scholz, Markus; Liu, Xueping; Iñiguez, Carmen; Raitakari, Olli T; Bacelis, Jonas; Schnurr, Theresia M; Lakka, Timo A; Ntalla, Ioanna; Lind, Mads V; Lauritzen, Lotte et al (BioMed Central Ltd, 2022)
      Background Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total ...

    • Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits 

      Sun, Daokun; Richard, Melissa A.; Musani, Solomon K.; Sung, Yun Ju; Winkler, Thomas W.; Schwander, Karen; Chai, Jin Fang; Guo, Xiuqing; Kilpeläinen, Tuomas O.; Vojinovic, Dina; Aschard, Hugues; Bartz, Traci M.; Bielak, Lawrence F.; Brown, Michael R.; Chitrala, Kumaraswamy; Hartwig, Fernando P.; Horimoto, Andrea R.V.R.; Liu, Yongmei; Manning, Alisa K.; Noordam, Raymond et al. [incl. Heikkinen, Sami; Lakka, Timo] (Elsevier BV, 2021)
      Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses ...
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    • No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease 

      Lupton MK; Benyamin B; Proitsi P; Nyholt DR; Ferreira MA; Montgomery GW; Heath AC; Madden PA; Medland SE; Gordon SD; Lovestone S; Tsolaki M; Kloszewska I; Soininen H; Mecocci P; Vellas B; Powell JF; Bush AI; Wright MJ; Martin NG; Whitfield JB (IOS Press, 2017)
      Iron deposition in the brain is a prominent feature of Alzheimer’s disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations ...
      info:eu-repo/semantics/article