Now showing items 1-4 of 4

    • BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF 

      Pulkkinen, H H; Kiema, M; Lappalainen, J P; Toropainen, A; Beter, M; Tirronen, A; Holappa, L; Niskanen, H; Kaikkonen, M U; Ylä-Herttuala, S; Laakkonen, Johanna P (Springer Science and Business Media LLC, 2021)
      The BMP/TGFβ-Smad, Notch and VEGF signaling guides formation of endothelial tip and stalk cells. However, the crosstalk of bone morphogenetic proteins (BMPs) and vascular endothelial growth factor receptor 2 (VEGFR2) ...
      Tieteelliset aikakauslehtiartikkelit

    • EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF 

      Groppa, E; Brkic, S; Uccelli, A; Wirth, G; Korpisalo-Pirinen, P; Filippova, M; Dasen. B; Sacchi, V; Muraro, MG; Trani, M; Reginato, S; Gianni-Barrera, R; Ylä-Herttuala, S; Banfi A (EMBO, 2018)
      Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis, whose best‐understood mechanism is sprouting. However, therapeutic VEGF delivery to ischemic muscle induces angiogenesis by the alternative ...
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    • Human Vascular Endothelial Growth Factor A165 Expression Induces the Mouse Model of Neovascular Age-Related Macular Degeneration 

      Kokki, E; Karttunen, T; Olsson, V; Kinnunen, K; Ylä-Herttuala, S (MDPI AG, 2018)
      Vascular endothelial growth factor (VEGF) expression induces age-related macular degeneration (AMD), which is a common vision-threatening disease due to choroidal neovascularization and a fibrovascular membrane. We describe ...
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    • MicroRNA-15b Targets VEGF and Inhibits Angiogenesis in Proliferative Diabetic Retinopathy 

      Yang, Ying; Liu, Yan; Li, Yiping; Chen, Zhongli; Xiong, Yixin; Zhou, Taicheng; Tao, Wenyu; Xu, Fan; Yang, Hanling; Ylä-Herttuala, Seppo; Chaurasia, Shyam S; Whaley-Connell, Adam; Yang, Ke (The Endocrine Society, 2020)
      Background Vascular endothelial growth factor (VEGF)-induced angiogenesis is a critical compensatory response to microvascular rarefaction in the diabetic retina that contributes to proliferative diabetic retinopathy ...
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