Browsing Terveystieteiden tiedekunta by Title
Now showing items 1-20 of 750
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1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) Inhibitors
(MDPI AG, 2018)We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4 ... -
24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial
(Elsevier BV, 2017)Background Nutrition is an important modifiable risk factor in Alzheimer's disease. Previous trials of the multinutrient Fortasyn Connect showed benefits in mild Alzheimer's disease dementia. LipiDiDiet investigated the ... -
25 years of advances in the definition, classification and treatment of status epilepticus
(Elsevier BV, 2016)Purpose Status epilepticus (SE) requires not only urgent symptomatic treatment with antiepileptic drugs but also rapid identification and treatment of its cause. This narrative review summarizes the most important advances ... -
A century of trends in adult human height
(eLife Sciences Organisation, Ltd., 2016)Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height ... -
A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs
(Springer Nature, 2016)Background Attention deficit hyperactivity disorder (ADHD) is a prevalent and multifactorial neuropsychiatric disorder in the human population worldwide. Complex etiology and clinical heterogeneity have challenged the ... -
A peer-support lifestyle intervention for preventing type 2 diabetes in India: A cluster-randomized controlled trial of the Kerala Diabetes Prevention Program.
(Public Library of Science (PLoS), 2018)Background The major efficacy trials on diabetes prevention have used resource-intensive approaches to identify high-risk individuals and deliver lifestyle interventions. Such strategies are not feasible for wider ... -
A prospective, randomized, open label, controlled study investigating the efficiency and safety of 3 different methods of rectus sheath block analgesia following midline laparotomy
(Ovid Technologies (Wolters Kluwer Health), 2018)Background: There is a controversy regarding the efficacy of rectus sheath block (RSB). The aim of the present study was to evaluate analgesic efficacy and safety of three different methods of RSB in postoperative pain ... -
A retrospective cross-sectional study of antibiotics prescribing patterns in admitted patients at a tertiary care setting in the KSA
(2018)Objective: Little is known about the pattern of antibiotics’ prescribing for hospitalized adult patients in the Kingdom of Saudi Arabia. This study explored the prescribing practices of antibiotics in a large tertiary ... -
Abortion debates in Finland and the Republic of Ireland: textual analysis of experiential thinking and argumentation in parliamentary and layperson discussions
(Springer Nature, 2017)Background The ethical discussion about abortion has been polarized in Finland and the Republic of Ireland, two European countries with very different abortion legislation (liberal vs. highly restrictive). The aim of the ... -
Abortion debates in Finland and the Republic of Ireland: textual analysis of experiential thinking and argumentation in parliamentary and layperson discussions
(Springer NatureBritannia, 2017)Background The ethical discussion about abortion has been polarized in Finland and the Republic of Ireland, two European countries with very different abortion legislation (liberal vs. highly restrictive). The aim of the ... -
Accelerated pharmaceutical protein development with integrated cell free expression, purification, and bioconjugation
(Springer Nature America, Inc, 2018)The use of living cells for the synthesis of pharmaceutical proteins, though state-of-the-art, is hindered by its lengthy process comprising of many steps that may affect the protein’s stability and activity. We aimed to ... -
Activating the Chromatin by Noncoding RNAs
(Mary Ann Liebert Inc, 2017)Significance: The extent and breadth of transcription have recently been uncovered and this has revealed an extensive array of noncoding RNAs (ncRNAs). The biological role and significance of these ncRNAs have been realized ... -
Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver
(Elsevier BV, 2018)Pregnane X receptor (PXR) is a nuclear receptor that senses chemical environment and is activated by numerous clinically used drugs and environmental contaminants. Previous studies have indicated that several drugs known ... -
Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart
(Elsevier BV, 2017)Objective Cardiac hexokinase II (HKII) can translocate between cytosol and mitochondria and change its cellular expression with pathologies such as ischemia–reperfusion, diabetes and heart failure. The cardiac metabolic ... -
Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome
(Springer Nature, 2017)Therapeutic treatment options for central nervous system diseases are greatly limited by the blood-brain barrier (BBB). Focused ultrasound (FUS), in conjunction with circulating microbubbles, can be used to induce a targeted ... -
Acute effects of visits to urban green environments on cardiovascular physiology in women: A field experiment subtitle:
(Elsevier BV, 2017)Background Epidemiological studies have reported positive associations between the amount of green space in the living environment and mental and cardiovascular human health. In a search for effect mechanisms, field studies ... -
Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose
(Ivyspring International Publisher, 2017)Rationale: Focused ultrasound (FUS), in conjunction with circulating microbubbles (MBs), can be used to transiently increase the permeability of the blood-brain barrier (BBB) in a targeted manner, allowing therapeutic ... -
Adenosine promotes endplate nAChR channel activity in adult mouse skeletal muscle fibres via low affinity P1 receptors
(Elsevier BV, 2018)Adenosine is a powerful modulator of skeletal neuromuscular transmission, operating via inhibitory or facilitatory purinergic-type P1 receptors. To date, studies have been focused mainly on the effect of adenosine on ... -
Adenoviral intramyocardial VEGF-DdeltaNdeltaC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up
(Oxford University Press (OUP), 2017)Aims We evaluated for the first time the effects of angiogenic and lymphangiogenic AdVEGF-DΔNΔC gene therapy in patients with refractory angina. Methods and results Thirty patients were randomized to AdVEGF-DΔNΔC ... -
Adherence to a Mediterranean-style diet and incident fractures: pooled analysis of observational evidence
(Springer Nature, 2017)Purpose The Mediterranean diet is associated with decreased morbidity and mortality from various chronic diseases. Adherence to a Mediterranean-style diet has been suggested to have protective effects on bone health and ...
