Search
Now showing items 1-10 of 12
Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus
(IOS Press, 2017)
articleartikkeli
Background:
Idiopathic normal pressure hydrocephalus (iNPH) is a late onset, surgically treated progressive brain disease caused by impaired cerebrospinal fluid dynamics and subsequent ventriculomegaly. Comorbid Alzheimer’s ...
Tolerability of ORM-12741 and effects on episodic memory in patients with Alzheimer's disease
(Elsevier BV, 2017)
articleartikkeli
Introduction
ORM-12741 is a novel selective antagonist of alpha-2C adrenoceptors. This trial evaluated the safety and efficacy of ORM-12741 in patients with Alzheimer's disease (AD).
Methods
A randomized, double-blind, ...
Five-class differential diagnostics of neurodegenerative diseases using random undersampling boosting
(2017)
articleartikkeli
Differentiating between different types of neurodegenerative diseases is not only crucial in clinical practice when treatment decisions have to be made, but also has a significant potential for the enrichment of clinical ...
Improving data sharing in research with context-free encoded missing data
(2017)
articleartikkeli
Lack of attention to missing data in research may result in biased results, loss of power and reduced generalizability. Registering reasons for missing values at the time of data collection, or—in the case of sharing ...
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
(Springer Nature, 2017)
articleartikkeli
Background
DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain ...
Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology
(Springer Nature, 2016)
articleartikkeli
A recent genome-wide association meta-analysis for Alzheimer’s disease (AD) identified 19 risk loci (in addition to APOE) in which the functional genes are unknown. Using Drosophila, we screened 296 constructs targeting ...
Associations of CAIDE Dementia Risk Score with MRI, PIB-PET measures, and cognition
(2017)
articleartikkeli
Background: CAIDE Dementia Risk Score is the first validated tool for estimating dementia risk based on a midlife risk profile.
Objectives: This observational study investigated longitudinal associations of CAIDE Dementia ...
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology
(Springer Nature, 2017)
articleartikkeli
Background
Insulin resistance (IR) has previously been associated with an increased risk of developing Alzheimer’s disease (AD), although the relationship between IR and AD is not yet clear. Here, we examined the influence ...
Mitochondrial genes are altered in blood early in Alzheimer's disease
(Elsevier BV, 2017)
articleartikkeli
Although mitochondrial dysfunction is a consistent feature of Alzheimer's disease in the brain and blood, the molecular mechanisms behind these phenomena are unknown. Here we have replicated our previous findings demonstrating ...
Postmenopausal hormone therapy and Alzheimer disease. A prospective cohort study
(2017)
articleartikkeli
Objective: To explore the association between postmenopausal hormone therapy (HT) and Alzheimer disease (AD).
Methods: Twenty-year follow-up data from the Kuopio Osteoporosis Risk Factor and Prevention study cohort were ...