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Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer's Disease Patients
(MDPI, 2022)
ArtikkeliArticle
Olfaction is orchestrated by olfactory mucosal cells located in the upper nasal cavity. Olfactory dysfunction manifests early in several neurodegenerative disorders including Alzheimer’s disease, however, disease-related ...
Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer’s Disease Patients
(MDPI, 2022)
ArtikkeliArticle
Olfactory function, orchestrated by the cells of the olfactory mucosa at the rooftop of the nasal cavity, is disturbed early in the pathogenesis of Alzheimer’s disease (AD). Biometals including zinc and calcium are known ...
A Multi-Cohort Study of ApoE e4 and Amyloid-ß Effects on the Hippocampus in Alzheimer's Disease
(IOS Press, 2017)
articleartikkeli
The apolipoprotein E (APOE) gene has been consistently shown to modulate the risk of Alzheimer’s disease (AD). Here, using an AD and normal aging dataset primarily consisting of three AD multi-center studies (n = 1,781), ...
Melatonin receptor type 1A gene linked to Alzheimer's disease in old age
(Oxford University Press (OUP), 2018)
articleartikkeli
Disruption of the circadian rhythms is a frequent preclinical and clinical manifestation of Alzheimer’s disease. Furthermore, it has been suggested that shift work is a risk factor for Alzheimer’s disease. Previously, we ...
Incidence and Prevalence of Antiepileptic Medication Use in Community-Dwelling Persons with and without Alzheimer's Disease
(IOS Press, 2018)
articleartikkeli
Background:
Although antiepileptic drugs (AEDs) have a potential for adverse drug reactions in older populations, little is known about their use in relation to Alzheimer’s disease (AD) diagnosis.
Objectives:
In this ...
Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
(Frontiers Media SA, 2018)
ArtikkeliArticle
Ferroptosis is a newly described form of regulated cell death, distinct from apoptosis, necroptosis and other forms of cell death. Ferroptosis is induced by disruption of glutathione synthesis or inhibition of glutathione ...
The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer's Disease
(2017)
articleartikkeli
The role of interleukins (ILs) and oxidative stress (OS) in precipitating neurodegenerative diseases including sporadic Alzheimer’s disease (AD), requires further clarification. In addition to neuropathological ...
Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease
(Frontiers Media SA, 2018)
ArtikkeliArticle
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, which is clinically associated with a global cognitive decline and progressive loss of memory and reasoning. According to the prevailing amyloid cascade ...
Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a stud
(Springer Nature America, Inc, 2018)
articleartikkeli
Background
PQ912 is an inhibitor of the glutaminyl cyclase enzyme that plays a central role in the formation of synaptotoxic pyroglutamate-A-beta oligomers. We report on the first clinical study with PQ912 in subjects ...
Hospital-Treated Pneumonia Associated with Opioid Use Among Community Dwellers with Alzheimer's Disease
(IOS Press, 2019)
ArtikkeliArticle
Background:Pneumonia is a common cause for hospitalization and excess mortality among persons with Alzheimer’s disease (AD), but little research exists evaluating drug use as its risk factor. Objective:We investigated the ...