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Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)
(Springer Nature, 2016)
articleartikkeli
Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis ...
The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis
(Springer Nature, 2017)
articleartikkeli
High L-homoarginine (hArg) levels are directly associated with several risk factors for cardiometabolic diseases whereas low levels predict increased mortality in prospective studies. The biomarker role of hArg in young ...
A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling
(Springer Nature, 2017)
articleartikkeli
We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a stringently defined phenotype. Analysis of phenotypic variability led to the identification of a specific genetic risk factor that ...
The frequency and influence of dementia risk factors in prodromal Alzheimer's disease
(Elsevier BV, 2017)
articleartikkeli
We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and ...
The associations of serum n-6 polyunsaturated fatty acids with serum C-reactive protein in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
(Springer Nature, 2017)
articleartikkeli
Background/objectives
There are concerns that high intake of n-6 polyunsaturated fatty acids (PUFA) may promote inflammation, because the end-product of n-6 PUFA metabolism, arachidonic acid, is a precursor for pro-inflammatory ...
Perfluoroalkyl substances in human bone: concentrations in bones and effects on bone cell differentiation
(Springer Nature, 2017)
articleartikkeli
Perfluoroalkyl substances (PFAS), including two most commonly studied compounds perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are widely distributed environmental pollutants, used extensively earlier. ...
Month and Season of Birth as a Risk Factor for Alzheimer's Disease: A Nationwide Nested Case-control Study
(Korean Society for Preventive Medicine, 2016)
articleartikkeli
Objectives:
Season of birth, an exogenous indicator of early life environment, has been related to higher risk of adverse psychiatric outcomes but the findings for Alzheimer’s disease (AD) have been inconsistent. We ...
Associations of estimated delta-5-desaturase and delta-6-desaturase activities with stroke risk factors and risk of stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study
(Cambridge University Press (CUP), 2017)
articleartikkeli
Stroke is a leading cause of morbidity and mortality. The role of PUFA in reducing the risk of stroke is uncertain. The concentrations of PUFA in the human body are determined both by dietary intake and by activities of ...
Modified serpinA1 as risk marker for Parkinson's disease dementia: analysis of baseline data
(Springer Nature, 2016)
ArtikkeliArticle
Early detection of dementia in Parkinson disease is a prerequisite for preventive therapeutic approaches. Modified serpinA1 in cerebrospinal fluid (CSF) was suggested as an early biomarker for differentiation between ...