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dc.contributor.authorHalbgebauer, Steffen
dc.contributor.authorNagi, Magdalena
dc.contributor.authorKlafki, Hans
dc.contributor.authorHaußmann, Ute
dc.contributor.authorSteinacker, Petra
dc.contributor.authorOeckl, Patrick
dc.contributor.authorKassubek, Jan
dc.contributor.authorPinkhardt, Elmar
dc.contributor.authorLudolph, Albert C
dc.contributor.authorSoininen, Hilkka
dc.contributor.authorHerukka, Sanna-Kaisa
dc.contributor.authorWiltfang, Jens
dc.contributor.authorOtto, Markus
dc.date.accessioned2017-01-18T07:34:17Z
dc.date.available2017-01-18T07:34:17Z
dc.date.issued2016
dc.identifierhttp://doi.org/10.1038/srep26145fi_FI
dc.identifier.issn2045-2322
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/166
dc.descriptionArticle
dc.description.abstractEarly detection of dementia in Parkinson disease is a prerequisite for preventive therapeutic approaches. Modified serpinA1 in cerebrospinal fluid (CSF) was suggested as an early biomarker for differentiation between Parkinson patients with (PDD) or without dementia (PD). Within this study we aimed to further explore the diagnostic value of serpinA1. We applied a newly developed nanoscale method for the detection of serpinA1 based on automated capillary isoelectric focusing (CIEF). A clinical sample of 102 subjects including neurologically healthy controls (CON), PD and PDD patients was investigated. Seven serpinA1 isoforms of different charge were detected in CSF from all three diagnostic groups. The mean CSF signals of the most acidic serpinA1 isoform differed significantly (p < 0.01) between PDD (n = 29) and PD (n = 37) or CON (n = 36). Patients above the cut-off of 6.4 have a more than six times higher risk for an association with dementia compared to patients below the cut off. We propose this serpinA1 CIEF-immunoassay as a novel tool in predicting cognitive impairment in PD patients and therefore for patient stratification in therapeutic trials.fi_FI
dc.language.isoENfi_FI
dc.publisherSpringer Naturefi_FI
dc.relation.ispartofseriesScientific Reports
dc.relation.urihttp://doi.org/10.1038/srep26145fi_FI
dc.rightsCC-BY http://creativecommons.org/licenses/by/4.0/fi_FI
dc.subjectDiagnostic markersfi_FI
dc.subjectMolecular neurosciencefi_FI
dc.subjectRisk factorsfi_FI
dc.subjectNeurological disordersfi_FI
dc.titleModified serpinA1 as risk marker for Parkinson's disease dementia: analysis of baseline datafi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionpublisher's pdffi_FI
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id41023362
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Authorsfi_FI
dc.relation.doi10.1038/srep26145
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.relation.issn2045-2322
dc.relation.volume6


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