Skip to main contentSkip to search and navigation

UEF eREPOSITORY

    • English
    • suomi
  • English 
    • English
    • suomi
  • Login
View Item 
  •   Home
  • Artikkelit
  • Luonnontieteiden ja metsätieteiden tiedekunta
  • View Item
  •   Home
  • Artikkelit
  • Luonnontieteiden ja metsätieteiden tiedekunta
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Intra-night variation in apnea-hypopnea index affects diagnostics and prognostics of obstructive sleep apnea

Thumbnail
Files
Article (350.9Kb)
Self archived version
published version
Date
2019
Author(s)
Nikkonen, S
Töyräs, J
Mervaala, E
Myllymaa, S
Terrill, P
Leppänen, T
Unique identifier
10.1007/s11325-019-01885-5
Metadata
Show full item record
More information
Research Database SoleCris

Self-archived article

Citation
Nikkonen, S. Töyräs, J. Mervaala, E. Myllymaa, S. Terrill, P. Leppänen, T. (2019). Intra-night variation in apnea-hypopnea index affects diagnostics and prognostics of obstructive sleep apnea.  Sleep and breathing, 24, 379–386. 10.1007/s11325-019-01885-5.
Rights
© The Authors 2019
Licensed under
CC BY http://creativecommons.org/licenses/by/4.0/
Abstract

Background
Diagnostics of obstructive sleep apnea (OSA) is based on apnea-hypopnea index (AHI) determined as full-night average of occurred events. We investigate our hypothesis that intra-night variation in the frequency of obstructive events affects diagnostics and prognostics of OSA and should therefore be considered in clinical practice.

Methods
Polygraphic recordings of 1989 patients (mean follow-up 18.3 years) with suspected OSA were analyzed. Number and severity of individual obstructive events were calculated hourly for the first 6 h of sleep. OSA severity was determined based on the full-night AHI and AHI for the 2 h when the obstructive event frequency was highest (AHI2h). Hazard ratios for all-cause, cardiovascular, and non-cardiovascular mortalities were calculated for different OSA severity categories based on the full-night AHI and AHI2h.

Results
Frequency and duration of obstructive events varied hour-by-hour increasing towards morning. Using AHI2h led to a statistically significant rearrangement of patients between the OSA severity categories. The use of AHI2h for severity classification showed clearer relationship between the OSA severity and mortality than the full-night AHI.

Conclusions
Currently, the intra-night variation in frequency and severity of obstructive events is completely ignored by conventional, full-night AHI and considering this information could improve the diagnostics of OSA.

URI
https://erepo.uef.fi/handle/123456789/24538
Link to the original item
http://dx.doi.org/10.1007/s11325-019-01885-5
Publisher
Springer Science and Business Media LLC
Collections
  • Luonnontieteiden ja metsätieteiden tiedekunta [1109]
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
OpenUEF
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap
Search

Browse

All of the ArchiveResource types & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subjectThis CollectionBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subject

My Account

Login
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
OpenUEF
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap