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Data from: Antiepileptic drug use and mortality among community-dwelling persons with Alzheimer's disease

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Date
2021-03-18
Author(s)
Sarycheva, Tatyana,University of Eastern Finland
Lavikainen, Piia,University of Eastern Finland
Taipale, Heidi,University of Eastern Finland
Tiihonen, Jari,Karolinska Institute
Tanskanen, Antti,Karolinska Institute
Hartikainen, Sirpa,University of Eastern Finland
Tolppanen, Anna-Maija,University of Eastern Finland
Unique identifier
10.5061/dryad.q3b38p9
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Research data

Citation
Sarycheva, Tatyana,University of Eastern Finland. Lavikainen, Piia,University of Eastern Finland. Taipale, Heidi,University of Eastern Finland. Tiihonen, Jari,Karolinska Institute. Tanskanen, Antti,Karolinska Institute. Hartikainen, Sirpa,University of Eastern Finland. Tolppanen, Anna-Maija,University of Eastern Finland. , Data from: Antiepileptic drug use and mortality among community-dwelling persons with Alzheimer's disease, 2021, 10.5061/dryad.q3b38p9.
Abstract

Objective: To evaluate the risk of death in relation to incident antiepileptic drug use compared with non-use in people with Alzheimer's disease (AD) through the assessment in terms of duration of use, specific drugs and main causes of death. Methods: The MEDALZ cohort includes all Finnish persons who received a clinically verified AD diagnosis (N=70718) in 2005‒2011. Incident AED users were identified with 1-year washout period. For each incident AED user (n=5638) one non-user was matched according to sex, age and time since AD diagnosis. Analyses were conducted with Cox proportional hazards models and inverse probability of treatment weighting (IPTW). Results: Nearly 50% discontinued AEDs within six months. Compared with non-users, AED users had an increased relative risk of death (IPTW hazard ratio (HR): 1.23; 95% CI: 1.12‒1.36). This was mainly due to deaths from dementia (IPTW HR: 1.62, 95% CI: 1.42‒1.86). There was no difference in cardio- and cerebrovascular deaths (IPTW HR: 0.98, 95% CI: 0.67‒1.44). The overall mortality was highest during the first 90 days of AED use (IPTW HR: 2.40, 95% CI: 1.91‒3.03). Among users of older AEDs relative risk of death was greater compared to users of newer AED use (IPTW HR: 1.79, 95% CI: 1.52‒2.16). Conclusions: In old vulnerable population with cognitive disorder, careful consideration of AED initiation and close adverse events monitoring are needed.

Subjects
Humans   Homo Sapiens   Alzheimer's disease   Current period   
URI
https://erepo.uef.fi/handle/123456789/24664
Link to the original item
https://zenodo.org/record/4619037
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  • Avoimet tutkimusaineistot [288]

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