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dc.contributor.authorVerma, Amit Kumar
dc.contributor.authorBharti, Prahalad Singh
dc.contributor.authorRafat, Sahar
dc.contributor.authorBhatt, Deepti
dc.contributor.authorGoyal, Yamini
dc.contributor.authorPandey, Kamlesh Kumar
dc.contributor.authorRanjan, Sanjeev
dc.contributor.authorAlmatroodi, Saleh A
dc.contributor.authorAlsahli, Mohammed A
dc.contributor.authorRahmani, Arshad Husain
dc.contributor.authorAlmatroudi, Ahmad
dc.contributor.authorDev, Kapil
dc.date.accessioned2021-04-07T11:18:56Z
dc.date.available2021-04-07T11:18:56Z
dc.date.issued2021
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/24757
dc.description.abstractAutophagy, a catabolic process, degrades damaged and defective cellular materials through lysosomes, thus working as a recycling mechanism of the cell. It is an evolutionarily conserved and highly regulated process that plays an important role in maintaining cellular homeostasis. Autophagy is constitutively active at the basal level; however, it gets enhanced to meet cellular needs in various stress conditions. The process involves various autophagy-related genes that ultimately lead to the degradation of targeted cytosolic substrates. Many factors modulate both upstream and downstream autophagy pathways like nutritional status, energy level, growth factors, hypoxic conditions, and localization of p53. Any problem in executing autophagy can lead to various pathological conditions including neurodegeneration, aging, and cancer. In cancer, autophagy plays a contradictory role; it inhibits the formation of tumors, whereas, during advanced stages, autophagy promotes tumor progression. Besides, autophagy protects the tumor from various therapies by providing recycled nutrition and energy to the tumor cells. Autophagy is stimulated by tumor suppressor proteins, whereas it gets inhibited by oncogenes. Due to its dynamic and dual role in the pathogenesis of cancer, autophagy provides promising opportunities in developing novel and effective cancer therapies along with managing chemoresistant cancers. In this article, we summarize different strategies that can modulate autophagy in cancer to overcome the major obstacle, i.e., resistance developed in cancer to anticancer therapies.
dc.language.isoenglanti
dc.publisherHindawi Limited
dc.relation.ispartofseriesOxidative medicine and cellular longevity
dc.relation.urihttp://dx.doi.org/10.1155/2021/8832541
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.titleAutophagy Paradox of Cancer: Role, Regulation, and Duality
dc.description.versionpublished version
dc.contributor.departmentSchool of Medicine / Biomedicine
uef.solecris.id77200209en
dc.type.publicationTieteelliset aikakauslehtiartikkelit
dc.rights.accessrights© 2021 Amit Kumar Verma et al.
dc.relation.doi10.1155/2021/8832541
dc.description.reviewstatuspeerReviewed
dc.relation.articlenumber8832541
dc.relation.issn1942-0900
dc.relation.volume2021
dc.rights.accesslevelopenAccess
dc.type.okmA2
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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