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dc.contributor.authorLampela Pasi
dc.contributor.authorTaipale Heidi
dc.contributor.authorLavikainen Piia
dc.contributor.authorHartikainen Sirpa
dc.date.accessioned2017-02-03T13:11:00Z
dc.date.available2017-02-03T13:11:00Z
dc.date.issued2016-10-31
dc.identifier10.1016/j.archger.2016.10.014fi_FI
dc.identifier.issn0167-4943
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/250
dc.descriptionArticle
dc.description.abstractBackground Older people often use multiple drugs, and some of them have anticholinergic activity. Anticholinergic drugs may cause adverse reactions, and therefore their use should be limited. To identify anticholinergic load, several ranked lists with different drugs and scoring systems have been developed and used widely in research. We investigated, if a comprehensive geriatric assessment (CGA) decreased the anticholinergic drug score in a 4-year period. We used four different anticholinergic ranked lists to determine the anticholinergic score and to describe how the results differ depending on the list used. Methods We analyzed data from population-based intervention study, in which a random sample of 1000 persons aged ≥75 years were randomized to either an intervention group or a control group. Those in the intervention group underwent CGA including medication assessment annually between 2004 and 2007. Current medication use was assessed annually. The anticholinergic load was calculated by using four ranked lists of anticholinergic drugs (Boustani’s, Carnahan’s, Chew’s and Rudolph’s) for each person and for each year. Results CGA had no statistically significant effect on anticholinergic exposure during the 4-year follow-up, but improvements towards more appropriate medication use were observed especially in the intervention group. However, age, gender and functional comorbidity index were associated to higher anticholinergic exposure, depending on the list used. Conclusions Repeated CGAs may result as more appropriate anticholinergic medication use. The selection of the list may affect the results and therefore the selection of the list is important.fi_FI
dc.language.isoengfi_FI
dc.publisherElsevier BVfi_FI
dc.relation.ispartofseriesARCHIVES OF GERONTOLOGY AND GERIATRICS (LIMERICK);
dc.relation.urihttp://dx.doi.org/10.1016/j.archger.2016.10.014fi_FI
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAnticholinergic drugsfi_FI
dc.subjectComprehensive geriatric assessmentfi_FI
dc.subjectOlder peoplefi_FI
dc.titleThe effect of comprehensive geriatric assessment on anticholinergic exposure assessed by four ranked anticholinergic listsfi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionfinal draftfi_FI
dc.contributor.departmentSchool of Pharmacy, Activities
uef.solecris.id43415246
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Elsevier Inc.
uef.citationinfo.issue68
uef.citationinfo.pages195-201
dc.relation.doi10.1016/j.archger.2016.10.014
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.format.pagerange195-201
dc.relation.issn0167-4943
dc.relation.issue68
dc.rights.accesslevelopenAccess


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