dc.contributor.author | Lupton MK | |
dc.contributor.author | Benyamin B | |
dc.contributor.author | Proitsi P | |
dc.contributor.author | Nyholt DR | |
dc.contributor.author | Ferreira MA | |
dc.contributor.author | Montgomery GW | |
dc.contributor.author | Heath AC | |
dc.contributor.author | Madden PA | |
dc.contributor.author | Medland SE | |
dc.contributor.author | Gordon SD | |
dc.contributor.author | Lovestone S | |
dc.contributor.author | Tsolaki M | |
dc.contributor.author | Kloszewska I | |
dc.contributor.author | Soininen H | |
dc.contributor.author | Mecocci P | |
dc.contributor.author | Vellas B | |
dc.contributor.author | Powell JF | |
dc.contributor.author | Bush AI | |
dc.contributor.author | Wright MJ | |
dc.contributor.author | Martin NG | |
dc.contributor.author | Whitfield JB | |
dc.date.accessioned | 2017-06-19T11:56:11Z | |
dc.date.available | 2017-06-19T11:56:11Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.3233/JAD-170027 | fi_FI |
dc.identifier.issn | 1387-2877 | |
dc.identifier.uri | https://erepo.uef.fi/handle/123456789/2616 | |
dc.description | Article | |
dc.description.abstract | Iron deposition in the brain is a prominent feature of Alzheimer’s disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology. | fi_FI |
dc.language.iso | EN | fi_FI |
dc.publisher | IOS Press | fi_FI |
dc.relation.ispartofseries | Journal of Alzheimer's Disease | |
dc.relation.uri | http://dx.doi.org/10.3233/JAD-170027 | fi_FI |
dc.rights | In copyright 1.0 | |
dc.subject | Alzheimer’s disease | fi_FI |
dc.subject | apolipoproteins E | fi_FI |
dc.subject | dementia | fi_FI |
dc.subject | ferritin | fi_FI |
dc.subject | genetic profile scores | fi_FI |
dc.subject | genome-wide association study | fi_FI |
dc.subject | iron | fi_FI |
dc.subject | population genetics | fi_FI |
dc.subject | transferrin | fi_FI |
dc.title | No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease | fi_FI |
dc.type | http://purl.org/eprint/type/JournalArticle | |
dc.description.version | final draft | fi_FI |
dc.contributor.department | Faculty of Health Sciences, shared activities | |
uef.solecris.id | 47618144 | |
eprint.status | http://purl.org/eprint/status/PeerReviewed | fi_FI |
dc.type.publication | info:eu-repo/semantics/article | |
uef.citationinfo.issue | Published: 30 May 2017 | |
dc.relation.doi | 10.3233/JAD-170027 | |
dc.description.reviewstatus | http://purl.org/eprint/status/PeerReviewed | |
dc.relation.issn | 1387-2877 | |
dc.relation.issue | Published: 30 May 2017 | |
dc.rights.accesslevel | openAccess | |
dc.rights.copyright | © IOS Press and the authors | |
dc.type.displayType | article | en |
dc.type.displayType | artikkeli | fi |
dc.rights.url | https://rightsstatements.org/page/InC/1.0/ | |