Show simple item record

dc.contributor.authorVirtanen JK
dc.contributor.authorGiniatullin R
dc.contributor.authorMäntyselkä P
dc.contributor.authorVoutilainen S
dc.contributor.authorNurmi T
dc.contributor.authorMursu J
dc.contributor.authorKauhanen J
dc.contributor.authorTuomainen TP
dc.date.accessioned2017-06-21T11:24:58Z
dc.date.available2017-06-21T11:24:58Z
dc.date.issued2017
dc.identifier10.1038/srep39697fi_FI
dc.identifier.issn2045-2322
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/2619
dc.descriptionArticle
dc.description.abstractVitamin D has been suggested to have a role in various neurovascular diseases, but the data regarding headache is inconclusive. Our aim was to investigate the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker for vitamin D status, and risk of frequent headache. The study population consisted of 2601 men from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) from eastern Finland, aged 42–60 years in 1984–1989. The cross-sectional associations with prevalence of self-reported frequent headache (defined as weekly or daily headaches) were estimated with multivariable-adjusted odds ratios. The average serum 25(OH) concentration was 43.4 nmol/L (SD 18.9, min-max 7.8–136.1 nmol/L). A total of 250 men (9.6%) reported frequent headache. The average serum 25(OH)D concentration among those with frequent headache was 38.3 nmol/L (SD 18.8) and 43.9 nmol/L (SD 18.9) among those without frequent headache, after adjustment for age and year and month of blood draw (P for difference <0.001). After multivariable adjustments, those in the lowest vs. the highest serum 25(OH)D quartile had 113% (95% CI 42, 218%; P for trend <0.001) higher odds for frequent headache. In conclusion, low serum 25(OH)D concentration was associated with markedly higher risk of frequent headache in men.fi_FI
dc.language.isoENfi_FI
dc.publisherSpringer Naturefi_FI
dc.relation.ispartofseriesScientific Reports
dc.relation.urihttp://doi.org/10.1038/srep39697fi_FI
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/fi_FI
dc.titleLow serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older menfi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionPublisher's pdffi_FI
dc.contributor.departmentA.I. Virtanen -instituutti
dc.contributor.departmentSchool of Medicine / Public Health,School of Medicine / Clinical Nutrition,School of Medicine / Biomedicine
uef.solecris.id47673348
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© The Authorsfi_FI
dc.relation.doi10.1038/srep39697
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.relation.articlenumber39697
dc.relation.issn2045-2322
dc.relation.volume7


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record