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dc.contributor.authorDaneshmand R
dc.contributor.authorKurl S
dc.contributor.authorTuomainen TP
dc.contributor.authorVirtanen JK
dc.date.accessioned2017-06-26T10:54:20Z
dc.date.available2017-06-26T10:54:20Z
dc.date.issued2017
dc.identifier10.1017/S000711451700054Xfi_FI
dc.identifier.issn0007-1145
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/2622
dc.descriptionArticle
dc.description.abstractStroke is a leading cause of morbidity and mortality. The role of PUFA in reducing the risk of stroke is uncertain. The concentrations of PUFA in the human body are determined both by dietary intake and by activities of desaturase enzymes. Desaturase enzymes have been associated with chronic diseases, but little is known about their association with stroke risk. We investigated the associations of Δ-6-desaturase (D6D) and Δ-5-desaturase (D5D) activities with stroke risk factors and risk of stroke among 1842 men from the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study, aged 42–60 years and free of CVD at baseline in 1984–1989. ANCOVA and Cox regression models were used for the analyses. Whole serum desaturase activities were estimated as product:precursor ratios – γ-linolenic acid:linoleic acid for D6D and arachidonic acid:dihomo-γ-linolenic acid for D5D. Higher D6D activity was associated with higher systolic and diastolic blood pressure, BMI, serum insulin and TAG concentrations and worse homoeostatic model assessment (HOMA) indices. In contrast, higher D5D activity was associated with lower systolic and diastolic blood pressure, BMI, serum insulin, LDL-cholesterol, TAG and C-reactive protein concentrations, higher HDL-cholesterol concentration, and better HOMA indices. During the mean follow-up of 21·2 years, 202 stroke cases occurred. Neither D6D activity (multivariable-adjusted extreme-quartile hazard ratios (HR) 1·18; 95 % CI 0·80, 1·74) nor D5D activity (HR 1·06; 95 % CI 0·70, 1·60) were associated with stroke risk. In conclusion, higher D5D activity was favourably associated and higher D6D activity unfavourably associated with several stroke risk factors, but not with the risk of incident stroke.fi_FI
dc.language.isoENfi_FI
dc.publisherCambridge University Press (CUP)fi_FI
dc.relation.ispartofseriesBRITISH JOURNAL OF NUTRITION
dc.relation.urihttp://dx.doi.org/10.1017/S000711451700054Xfi_FI
dc.rightsAll rights reservedfi_FI
dc.subjectDesaturasesfi_FI
dc.subjectPUFAfi_FI
dc.subjectStroke risk factorsfi_FI
dc.subjectRisk factorsfi_FI
dc.subjectProspective studiesfi_FI
dc.titleAssociations of estimated delta-5-desaturase and delta-6-desaturase activities with stroke risk factors and risk of stroke: the Kuopio Ischaemic Heart Disease Risk Factor Studyfi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionfinal draftfi_FI
dc.contributor.departmentSchool of Medicine / Public Health
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id47673508
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Authors
uef.citationinfo.pages582-590
dc.relation.doi10.1017/S000711451700054X
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.format.pagerange582-590
dc.relation.issn0007-1145
dc.relation.issue4
dc.relation.volume117


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