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dc.contributor.authorYlä-Herttuala S
dc.contributor.authorBaker AH
dc.date.accessioned2017-06-26T11:05:45Z
dc.date.available2017-06-26T11:05:45Z
dc.date.issued2017
dc.identifier10.1016/j.ymthe.2017.03.027
dc.identifier.issn1525-0016
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/2623
dc.descriptionArticle
dc.description.abstractCardiovascular diseases remain a large global health problem. Although several conventional small-molecule treatments are available for common cardiovascular problems, gene therapy is a potential treatment option for acquired and inherited cardiovascular diseases that remain with unmet clinical needs. Among potential targets for gene therapy are severe cardiac and peripheral ischemia, heart failure, vein graft failure, and some forms of dyslipidemias. The first approved gene therapy in the Western world was indicated for lipoprotein lipase deficiency, which causes high plasma triglyceride levels. With improved gene delivery methods and more efficient vectors, together with interventional transgene strategies aligned for a better understanding of the pathophysiology of these diseases, new approaches are currently tested for safety and efficacy in clinical trials. In this article, we integrate a historical perspective with recent advances that will likely affect clinical development in this research area.
dc.language.isoEN
dc.publisherElsevier BV
dc.relation.ispartofseriesMOLECULAR THERAPY
dc.relation.urihttp://dx.doi.org/10.1016/j.ymthe.2017.03.027
dc.rightsAll rights reserved
dc.subjectcardiovascular gene therapy
dc.subjectclinical trials
dc.subjecthyperlipidemias
dc.subjectischemia
dc.subjectheart failure
dc.subjectendpoints
dc.subjecttrial design
dc.titleCardiovascular gene therapy : past, present, and future
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionfinal draft
dc.contributor.departmentA.I. Virtanen -instituutti
uef.solecris.id47673733
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© The American Society of Gene and Cell Therap
uef.citationinfo.issue25(5)
uef.citationinfo.pages1095-1106
dc.relation.doi10.1016/j.ymthe.2017.03.027
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.format.pagerange1095-1106
dc.relation.issn1525-0016
dc.relation.issue5
dc.relation.volume25
dc.rights.accesslevelopenAccess
dc.type.versioninfo:eu-repo/semantics/acceptedVersion


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