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dc.contributor.authorIkäheimo TM
dc.contributor.authorJokelainen J
dc.contributor.authorHassi J
dc.contributor.authorHiltunen L
dc.contributor.authorKeinänen-Kiukaanniemi S
dc.contributor.authorLaatikainen T
dc.contributor.authorJousilahti P
dc.contributor.authorPeltonen M
dc.contributor.authorMoilanen L
dc.contributor.authorSaltevo J
dc.contributor.authorNäyhä S
dc.date.accessioned2017-07-10T06:47:55Z
dc.date.available2017-07-10T06:47:55Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/2644
dc.description.abstractAims Diabetes and impaired glucose metabolism cause metabolic, neural and circulatory disturbances that may predispose to adverse cooling and related symptoms during the cold season. This study assessed the prevalence of cold-related cardiorespiratory symptoms in the general population according to glycaemic status. Methods The study population consisted of 2436 men and 2708 women aged 45–74 years who participated in the National FINRISK cold sub-studies in 2002 and 2007. A questionnaire assessed cold-related symptoms (respiratory, cardiac, peripheral circulation). Glycaemic status was determined based on fasting blood glucose, oral glucose tolerance tests or reported diagnosis of diabetes and categorized into normal glucose metabolism, impaired fasting blood glucose, impaired glucose tolerance, screening-detected type 2 diabetes and type 2 diabetes. Results Type 2 diabetes was associated with increased odds for cold-related dyspnoea [Adjusted OR 1.72 (95% CI, 1.28–2.30)], chest pain [2.10 (1.32–3.34)] and respiratory symptoms [1.85 (1.44–2.38)] compared with normal glucose metabolism. Screened type 2 diabetes showed increased OR for cold-related dyspnoea [1.36 (1.04–1.77)], cough [1.41 (1.06–1.87)] and cardiac symptoms [1.51 (1.04–2.20)]. Worsening of glycaemic status was associated with increased odds for cold-related dyspnoea (from 1.16 in impaired fasting glucose to 1.72 in type 2 diabetes, P = 0.000), cough (1.02–1.27, P = 0.032), chest pain (1.28–2.10, P = 0.006), arrhythmias (0.87–1.74, P = 0.020), cardiac (1.11–1.99, P = 0.000), respiratory (1.14–1.84, P = 0.000) and all symptoms (1.05–1.66, P = 0.003). Conclusions Subjects with diabetes and pre-diabetes experience more cold-related cardiorespiratory symptoms and need instructions for proper protection from cold weather to reduce adverse health effects.en
dc.language.isoENen
dc.publisherElsevier BVen
dc.relation.urihttp://doi.org/10.1016/j.diabres.2017.04.022en
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectCold temperatureen
dc.subjectSymptomsen
dc.subjectDiabetesen
dc.subjectImpaired glucose metabolismen
dc.titleDiabetes and impaired glucose metabolism is associated with more cold-related cardiorespiratory symptomsen
dc.description.versionfinal draften
dc.contributor.departmentSchool of Medicine / Public Healthen
uef.solecris.id47977943en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Elsevier BV
dc.relation.doi10.1016/j.diabres.2017.04.022en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange116-125en
dc.relation.issn0168-8227en
dc.relation.volume129en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.relation.ispartofjournalDIABETES RESEARCH AND CLINICAL PRACTICEen


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