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dc.contributor.authorNieminen Heikki J
dc.contributor.authorBarreto Goncalo
dc.contributor.authorFinnila Mikko A
dc.contributor.authorGarcia-Perez Alejandro
dc.contributor.authorSalmi Ari
dc.contributor.authorRanjan Sanjeev
dc.contributor.authorEklund Kari K
dc.contributor.authorPritzker Kenneth P H
dc.contributor.authorSaarakkala Simo
dc.contributor.authorHaeggstrom Edward
dc.date.accessioned2017-07-10T12:11:52Z
dc.date.available2017-07-10T12:11:52Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/2647
dc.description.abstractResearch is ongoing to develop drug therapies to manage osteoarthritis (OA) and articular cartilage (AC) injuries. However, means to deliver drug to localized AC lesions are highly limited and not clinically available. This study investigates the capability of laser ultrasound (laser-induced plasma sound source) to deliver agents (methylene blue, MB, in PBS) into bovine AC. Treatment samples (n = 10) were immersed in MB solution simultaneously with LU exposure, while adjacent control 1 tissue (n = 10) was pre-treated with LU followed by immersion in MB and adjacent control 2 tissue (n = 10) was only immersed in MB. AC exposed (n = 22) or not exposed (n = 27) to LU were characterized for anomalies in structure, composition, viability or RNA expression. Optically detected MB content was significantly (p < 0.01) higher in treatment samples up to a depth of 500 µm from AC surface as compared to controls. No major unwanted short-term effects on AC structure, proteoglycan or collagen contents, chondrocyte viability or RNA expression levels were detected. In conclusion, LU can deliver agents into AC without major short-term concerns on safety. LU could reveal new strategies for the development of localized drug therapies in AC.en
dc.language.isoENen
dc.publisherSpringer Natureen
dc.relation.urihttp://doi.org/10.1038/s41598-017-04293-5en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectAcousticsen
dc.subjectBiomedical engineeringen
dc.subjectCartilageen
dc.subjectOsteoarthritisen
dc.titleLaser-ultrasonic delivery of agents into articular cartilageen
dc.description.versionpublished versionen
dc.contributor.departmentDepartment of Applied Physics, activitiesen
uef.solecris.id48228861en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authors
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/336267//Development of 3D Histopathological Grading of Osteoarthritis/3D-OA-HISTOen
dc.relation.doi10.1038/s41598-017-04293-5en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumber3991en
dc.relation.issn2045-2322en
dc.relation.volume7en
dc.rights.accesslevelinfo:eu-repo/semantics/openAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.relation.ispartofjournalScientific Reportsen


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