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Novel genetic loci associated with hippocampal volume

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Date
2017
Author(s)
Hibar DP
Adams HH
Jahanshad N
Chauhan G
Stein JL
Hofer E
Renteria ME
Bis JC
Arias-Vasquez A
Ikram MK
Desrivières S
Vernooij MW
Abramovic L
Alhusaini S
Amin N
Andersson M
Arfanakis K
Aribisala BS
Armstrong NJ
Athanasiu L et al.
Unique identifier
10.1038/ncomms13624
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Citation
Hibar DP. Adams HH. Jahanshad N. Chauhan G. Stein JL. Hofer E. Renteria ME. Bis JC. Arias-Vasquez A. Ikram MK. Desrivières S. Vernooij MW. Abramovic L. Alhusaini S. Amin N. Andersson M. Arfanakis K. Aribisala BS. Armstrong NJ. Athanasiu L et al.. (2017). Novel genetic loci associated with hippocampal volume.  Nature Communications, 8, 1-1213624. 10.1038/ncomms13624.
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CC BY http://creativecommons.org/licenses/by/4.0/
Abstract

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

Subjects
Genome-wide association studies   Neurodegenerative diseases   
URI
https://erepo.uef.fi/handle/123456789/3712
Publisher
Springer Nature
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  • Terveystieteiden tiedekunta [1324]
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