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dc.contributor.authorHenn LL
dc.contributor.authorHughes J
dc.contributor.authorIisakka E
dc.contributor.authorEllermann J
dc.contributor.authorMortazavi S
dc.contributor.authorZiegler C
dc.contributor.authorNissi MJ
dc.contributor.authorMorgan P
dc.date.accessioned2017-08-23T10:17:38Z
dc.date.available2017-08-23T10:17:38Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/4236
dc.description.abstractFemoroacetabular impingement (FAI) is a condition in which subtle deformities of the femoral head and acetabulum (hip socket) result in pathological abutment during hip motion. FAI is a common cause of hip pain and can lead to acetabular cartilage damage and osteoarthritis. For some patients with FAI, surgical intervention is indicated, and it can improve quality of life and potentially delay the onset of osteoarthritis. For other patients, however, surgery is contraindicated because significant cartilage damage has already occurred. Unfortunately, current imaging modalities (X-rays and conventional MRI) are subjective and lack the sensitivity to distinguish these two groups reliably. In this paper, we describe the pairing of T2* mapping data (an investigational, objective MRI sequence) and a spatial proportional odds model for surgically obtained ordinal outcomes (Beck's scale of cartilage damage). Each hip in the study is assigned its own spatial dependence parameter, and a Dirichlet process prior distribution permits clustering of said parameters. Using the fitted model, we produce a six-color, patient-specific predictive map of the entire acetabular cartilage. Such maps will facilitate patient education and clinical decision making.en
dc.language.isoENen
dc.relation.ispartofseriesSTATISTICS IN MEDICINEen
dc.relation.urihttp://dx.doi.org/10.1002/sim.7213en
dc.rightsAll rights reserveden
dc.subjectareal modelen
dc.subjectarthroscopyen
dc.subjectBayesian composite likelihooden
dc.subjectcopulaen
dc.subjectDirichlet processen
dc.subjecthipen
dc.subjectosteoarthritisen
dc.subjectpersonalized medicineen
dc.subjectproportional oddsen
dc.subjectT2en
dc.titleDisease severity classification using quantitative magnetic resonance imaging data of cartilage in femoroacetabular impingementen
dc.description.versionfinal draften
dc.contributor.departmentDepartment of Applied Physics, activitiesen
uef.solecris.id48145902en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© John Wiley & Sons Ltden
dc.relation.doi10.1002/sim.7213en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange1491-1505en
dc.relation.issn0277-6715en
dc.relation.issue9en
dc.relation.volume36en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
uef.solecris.openaccessEi


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