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dc.contributor.authorFyhrquist P
dc.contributor.authorVirjamo V
dc.contributor.authorHiltunen E
dc.contributor.authorJulkunen-Tiitto R
dc.date.accessioned2017-08-25T10:14:38Z
dc.date.available2017-08-25T10:14:38Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/4240
dc.description.abstractThis study reports for the first time promising antibacterial and antifungal effects of epidihydropinidine, the major piperidine alkaloid in the needles and bark of Norway spruce, Picea abies (L.) Karsten. Epidihydropinidine was growth inhibitory against all bacterial and fungal strains used in our investigation, showing the lowest MIC value of 5.37 μg/mL against Pseudomonas aeruginosa, Enterococcus faecalis, Candida glabrata and C. albicans. Epidihydropinidine was nearly three times more active than tetracycline against P. aeruginosa and E. faecalis. Promising antibacterial effects were also recorded against Staphylococcus aureus and Bacillus cereus (MIC 10.75 μg/mL) as well as against Salmonella enterica (MIC and MBC 43 μg/mL). Our preliminary results suggest that epidihydropinidine as well related alkaloids of Norway spruce could be powerful candidates for new antibiotics and for preventing food spoilage.en
dc.language.isoENen
dc.relation.ispartofseriesFITOTERAPIAen
dc.relation.urihttp://dx.doi.org/10.1016/j.fitote.2017.01.011en
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectPicea abiesen
dc.subjectPiperidine alkaloidsen
dc.subjectEpidihydropinidineen
dc.subjectAntibacterialen
dc.subjectAnti-Candidaen
dc.titleEpidihydropinidine, the main piperidine alkaloid compound of Norway spruce (Picea abies) shows promising antibacterial and anti-Candida activityen
dc.description.versionfinal draften
dc.contributor.departmentYmpäristö- ja biotieteiden laitos / Toimintaen
uef.solecris.id46875527en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Elsevier B.Ven
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP5-JRC/1997/EU/Ageing materials evaluation and studies/AMESen
dc.relation.doi10.1016/j.fitote.2017.01.011en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange138-146en
dc.relation.issn0367-326Xen
dc.relation.volume117en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
uef.solecris.openaccessEi


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