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dc.contributor.authorChakraborty Mousumi
dc.contributor.authorRidgway Cathy
dc.contributor.authorBawuah Prince
dc.contributor.authorMarkl Daniel
dc.contributor.authorGane Patrick AC
dc.contributor.authorKetolainen Jarkko
dc.contributor.authorZeitler J Axel
dc.contributor.authorPeiponen Kai-Erik
dc.date.accessioned2017-09-12T08:29:41Z
dc.date.available2017-09-12T08:29:41Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/4265
dc.description.abstractThe objective of this study is to propose a novel optical compressibility parameter for porous pharmaceutical tablets. This parameter is defined with the aid of the effective refractive index of a tablet that is obtained from non-destructive and contactless terahertz (THz) time-delay transmission measurement. The optical compressibility parameter of two training sets of pharmaceutical tablets with a priori known porosity and mass fraction of a drug was investigated. Both pharmaceutical sets were compressed with one of the most commonly used excipients, namely microcrystalline cellulose (MCC) and drug Indomethacin. The optical compressibility clearly correlates with the skeletal bulk modulus determined by mercury porosimetry and the recently proposed terahertz lumped structural parameter calculated from terahertz measurements. This lumped structural parameter can be used to analyse the pattern of arrangement of excipient and drug particles in porous pharmaceutical tablets. Therefore, we propose that the optical compressibility can serve as a quality parameter of a pharmaceutical tablet corresponding with the skeletal bulk modulus of the porous tablet, which is related to structural arrangement of the powder particles in the tablet.en
dc.language.isoENen
dc.publisherElsevier BVen
dc.relation.ispartofseriesINTERNATIONAL JOURNAL OF PHARMACEUTICSen
dc.relation.urihttp://dx.doi.org/10.1016/j.ijpharm.2017.03.093en
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectPharmaceutical tableten
dc.subjectMicrocrystalline celluloseen
dc.subjectIndomethacinen
dc.subjectOptical compressibilityen
dc.subjectStructural parameteren
dc.subjectSkeletal bulk modulusen
dc.subjectTerahertzen
dc.titleOptics-based compressibility parameter for pharmaceutical tablets obtained with the aid of the terahertz refractive indexen
dc.description.versionfinal draften
dc.contributor.departmentDepartment of Physics and Mathematics, activitiesen
dc.contributor.departmentSchool of Pharmacy, Activitiesen
uef.solecris.id46710993en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Elsevier B.Ven
dc.relation.doi10.1016/j.ijpharm.2017.03.093en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange85-91en
dc.publisher.countryAlankomaaten
dc.relation.issn0378-5173en
dc.relation.issue1en
dc.relation.volume525en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
uef.solecris.openaccessEi


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