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dc.contributor.authorRochel Natacha
dc.contributor.authorMolnár Ferdinand
dc.date.accessioned2017-09-20T07:20:05Z
dc.date.available2017-09-20T07:20:05Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/4309
dc.description.abstract1α,25-Dihydroxvitamin D3 (1,25(OH)2D3) is the hormonally active form of vitamin D3. Its synthesis and its metabolites, their transport and elimination as well as action on transcriptional regulation involves the harmonic cooperation of diverse proteins with vitamin D binding capacities such as vitamin D binding protein (DBP), cytochrome P450 enzymes or the nuclear vitamin receptor (VDR). The genomic mechanism of 1,25(OH)2D3 action involves its binding to VDR that functionally acts as a heterodimer with retinoid X receptor. The crystal structures of the most important proteins for vitamin D3, VDR, DBP, CYP2R1 and CYP24A1, have provided identification of mechanisms of actions of these proteins and those mediating VDR-regulated transcription. This review will present the structural information on recognition of the vitamin D3 and metabolites by CYP proteins and DBP as well as the structural basis of VDR activation by 1,25(OH)2D3 and metabolites. Additionally, we will describe, the implications of the VDR mutants associated with hereditary vitamin D-resistant rickets (HVDRR) that display impaired function.en
dc.language.isoENen
dc.publisherElsevier BVen
dc.relation.ispartofseriesMOLECULAR AND CELLULAR ENDOCRINOLOGYen
dc.relation.urihttp://dx.doi.org/10.1016/j.mce.2017.02.046en
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectVitamin D3en
dc.subjectDBPen
dc.subjectCYPsen
dc.subjectVDRen
dc.subjectHVDRRen
dc.subjectStructureen
dc.subjectAllosteryen
dc.titleStructural aspects of Vitamin D endocrinologyen
dc.description.versionfinal draften
dc.contributor.departmentSchool of Pharmacy, Activitiesen
uef.solecris.id46520811en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Elsevier B.Ven
dc.relation.doi10.1016/j.mce.2017.02.046en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange22-35en
dc.relation.issn0303-7207en
dc.relation.volume453en
dc.rights.accesslevelopenAccessen
dc.type.okmA2en
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
uef.solecris.openaccessEi


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