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dc.contributor.authorOjarinta R
dc.contributor.authorLerminiaux L
dc.contributor.authorLaitinen R
dc.date.accessioned2017-09-20T10:30:25Z
dc.date.available2017-09-20T10:30:25Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/4317
dc.description.abstractCo-amorphous drug-amino acid mixtures have shown potential for improving the solid-state stability and dissolution behavior of amorphous drugs. In previous studies, however these mixtures have been produced mainly with small-scale preparation methods, or with methods that have required the use of organic solvents or other dissolution enhancers. In the present study, co-amorphous ibuprofen-arginine and indomethacin-arginine mixtures were spray dried from water. The mixtures were prepared at two drug-arginine molar ratios (1:1 and 1:2). The properties of the prepared mixtures were investigated with differential scanning calorimetry, X-ray powder diffractometry, Fourier-transform infrared spectroscopy and a 24 h, non-sink, dissolution study. All mixtures exhibited a single glass transition temperature (Tg), evidence of the formation of homogenous single-phase systems. Fourier transform infrared spectroscopy revealed strong interactions (mainly salt formation) that account for the positive deviation between measured and estimated Tg values. No crystallization was observed during a 1-year stability study in either 1:1 or 1:2 mixtures, but in the presence of moisture, handling difficulties were encountered. The formation of co-amorphous salts led to improved dissolution characteristics when compared to the corresponding physical mixtures or to pure crystalline drugs.en
dc.language.isoENen
dc.publisherElsevier BVen
dc.relation.ispartofseriesINTERNATIONAL JOURNAL OF PHARMACEUTICSen
dc.relation.urihttp://dx.doi.org/10.1016/j.ijpharm.2017.09.015en
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectCo-amorphousen
dc.subjectAmino aciden
dc.subjectSpray dryingen
dc.subjectStabilityen
dc.subjectDissolutionen
dc.titleSpray drying of poorly soluble drugs from aqueous arginine solutionen
dc.description.versionfinal draften
dc.contributor.departmentSchool of Pharmacy, Activitiesen
uef.solecris.id49503413en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Elsevier B.Ven
dc.relation.doi10.1016/j.ijpharm.2017.09.015en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange289-298en
dc.publisher.countryAlankomaaten
dc.relation.issn0378-5173en
dc.relation.issue1en
dc.relation.volume532en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
uef.solecris.openaccessEi


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