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dc.contributor.authorFerreri Florinda
dc.contributor.authorGuerra Andrea
dc.contributor.authorVollero Luca
dc.contributor.authorPonzo David
dc.contributor.authorMäättä Sara
dc.contributor.authorMervaala Esa
dc.contributor.authorIannello Giulio
dc.contributor.authorDi Lazzaro Vincenzo
dc.date.accessioned2017-09-29T11:58:31Z
dc.date.available2017-09-29T11:58:31Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/4343
dc.description.abstractThe sensorimotor cortical system undergoes structural and functional changes across its lifespan. Some of these changes are physiological and parallel the normal aging process, while others might represent pathophysiological mechanisms underlying neurodegenerative disorders. In the last years, the study of possible age-related modifications in brain sensorimotor functional characteristics has been the focus of several research projects. Here we have used the transcranial magnetic stimulation (TMS)-electroencephalography (EEG) navigated co-registration to investigate the influence of physiological aging on the excitability and connectivity of the human sensorimotor cortical system. To this end, we compared the TMS-evoked EEG potentials (TEPs) collected after stimulating the dominant primary motor cortex (M1) in healthy young subjects (mean age 24.5 years) with those collected in healthy older adults (mean age 67.6 years). We have shown that, after stimulation of the left motor cortex, TEPs are significantly affected by physiological aging. This phenomenon has a clear spatio-temporal specificity and we speculate that normal aging per se leads to some changes in the excitability of specific cortical neural assemblies whereas other alterations could reflect compensatory mechanisms to such changes.en
dc.language.isoENen
dc.publisherElsevier BVen
dc.relation.ispartofseriesNEUROSCIENCEen
dc.relation.urihttp://dx.doi.org/10.1016/j.neuroscience.2017.06.014en
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectnavigated transcranial magnetic stimulationen
dc.subjectTMS-EEG co-registrationen
dc.subjectmotor cortex excitabilityen
dc.subjectmotor cortex connectivityen
dc.subjectagingen
dc.titleAge-related changes of cortical excitability and connectivity in healthy humans: non-invasive evaluation of sensorimotor network by means of TMS-EEGen
dc.description.versionfinal draften
dc.contributor.departmentSchool of Medicine / Clinical Medicineen
uef.solecris.id48530033en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© IBROen
dc.relation.doi10.1016/j.neuroscience.2017.06.014en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange255-263en
dc.relation.issn0306-4522en
dc.relation.volume357en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
uef.solecris.openaccessEi


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