• English
    • suomi
  • English 
    • English
    • suomi
  • Login
View Item 
  •   Home
  • Artikkelit
  • Luonnontieteiden ja metsätieteiden tiedekunta
  • View Item
  •   Home
  • Artikkelit
  • Luonnontieteiden ja metsätieteiden tiedekunta
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

The effect of fixed charge density and cartilage swelling on mechanics of knee joint cartilage during simulated gait

Thumbnail
View/Open
Article (145.1Kb)
Self archived version
final draft
Date
2017
Author
Räsänen LP
Tanska P
Zbýn Š
van Donkelaar CC
Trattnig S
Nieminen MT
Korhonen RK
Unique identifier
10.1016/j.jbiomech.2017.06.041
Metadata
Show full item record
More information
Research Database SoleCris

Self-archived article

Citation
Räsänen LP. Tanska P. Zbýn Š. van Donkelaar CC. Trattnig S. Nieminen MT. Korhonen RK. (2017). The effect of fixed charge density and cartilage swelling on mechanics of knee joint cartilage during simulated gait.  JOURNAL OF BIOMECHANICS, 61, 34-44. 10.1016/j.jbiomech.2017.06.041.
Rights
© Elsevier B.V
Licensed under
CC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract

The effect of swelling of articular cartilage, caused by the fixed charge density (FCD) of proteoglycans, has not been demonstrated on knee joint mechanics during simulated walking before. In this study, the influence of the depth-wise variation of FCD was investigated on the internal collagen fibril strains and the mechanical response of the knee joint cartilage during gait using finite element (FE) analysis. The FCD distribution of tibial cartilage was implemented from sodium (23Na) MRI into a 3-D FE-model of the knee joint (“Healthy model”). For comparison, models with decreased FCD values were created according to the decrease in FCD associated with the progression of osteoarthritis (OA) (“Early OA” and “Advanced OA” models). In addition, a model without FCD was created (“No FCD” model). The effect of FCD was studied with five different collagen fibril network moduli of cartilage. Using the reference fibril network moduli, the decrease in FCD from “Healthy model” to “Early OA” and “Advanced OA” models resulted in increased axial strains (by +2 and +6%) and decreased fibril strains (by −3 and −13%) throughout the stance, respectively, calculated as mean values through cartilage depth in the tibiofemoral contact regions. Correspondingly, compared to the “Healthy model”, the removal of the FCD altogether in “NoFCD model” resulted in increased mean axial strains by +16% and decreased mean fibril strains by −24%. This effect was amplified as the fibril network moduli were decreased by 80% from the reference. Then mean axial strains increased by +6, +19 and +49% and mean fibril strains decreased by −9, −20 and −32%, respectively. Our results suggest that the FCD in articular cartilage has influence on cartilage responses in the knee during walking. Furthermore, the FCD is suggested to have larger impact on cartilage function as the collagen network degenerates e.g. in OA.

Subjects
Knee joint   Articular cartilage   Fixed charge density   Proteoglycans   Swelling   Gait   Finite element analysis   
URI
https://erepo.uef.fi/handle/123456789/4387
Link to the original item
http://dx.doi.org/10.1016/j.jbiomech.2017.06.041
Publisher
Elsevier BV
Collections
  • Luonnontieteiden ja metsätieteiden tiedekunta
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
Send Feedback
OpenUEF
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 

Browse

All of the ArchiveResource types & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
Send Feedback
OpenUEF
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog