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Targeted identification of adverse events in coronary artery disease patients based on patient-reported outcomes

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Item embargoed until 2018-10-17. Restrictions imposed by the publisher
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final draft
Date
2017
Author
Heiskanen J
Tolppanen A-M
Martikainen J
Hartikainen J
Miettinen H
Hippeläinen M
Roine RP
Unique identifier
10.2217/cer-2016-0091
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Citation
Heiskanen J. Tolppanen A-M. Martikainen J. Hartikainen J. Miettinen H. Hippeläinen M. Roine RP. (2017). Targeted identification of adverse events in coronary artery disease patients based on patient-reported outcomes.  Journal of Comparative Effectiveness Research, Published Online:17 Oct 2017, 10.2217/cer-2016-0091.
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© Future Medicine Ltd
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Abstract

Aim: Can focusing the adverse events search to patients with poor patient-reported outcome help in targeting adverse event detection? Patients & methods: Coronary artery revascularization patients of the Kuopio University Hospital from June 2012 to August 2014 categorized into those with clinically significant improvement (15D score change ≥0.015, n = 81) or deterioration (change ≥-0.015, n = 64) in post-intervention health-related quality of life. Results: Major complications (27 vs 9%, p = 0.004) or post-intervention infections (16 vs 5%, p = 0.031) were more common among those with deteriorated score. They also tended to have more cardiovascular (19 vs 9%, p = 0.071) and minor complications (16 vs 7%, p = 0.118). Conclusion: Patient-reported outcomes may potentially help in targeting the adverse events search so that a larger number of adverse events can be identified for efficient learning from them.

Subjects
cardiology/cardiovascular   comparative safety   patient-reported outcomes   
URI
https://erepo.uef.fi/handle/123456789/4415
Link to the original item
http://dx.doi.org/10.2217/cer-2016-0091
Publisher
Future Medicine Ltd
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  • Terveystieteiden tiedekunta
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