Show simple item record

dc.contributor.authorEgea J
dc.contributor.authorFabregat I
dc.contributor.authorFrapart YM
dc.contributor.authorGhezzi P
dc.contributor.authorGörlach A
dc.contributor.authorKietzmann T
dc.contributor.authorKubaichuk K
dc.contributor.authorKnaus UG
dc.contributor.authorLopez MG
dc.contributor.authorOlaso-Gonzalez G
dc.contributor.authorPetry A
dc.contributor.authorSchulz R1
dc.contributor.authorVina J
dc.contributor.authorWinyard P
dc.contributor.authorAbbas K
dc.contributor.authorAdemowo OS
dc.contributor.authorAfonso CB
dc.contributor.authorAndreadou I
dc.contributor.authorAntelmann H
dc.contributor.authorAntunes F
dc.contributor.authorAslan M
dc.contributor.authorBachschmid MM
dc.contributor.authorBarbosa RM
dc.contributor.authorBelousov V
dc.contributor.authorBerndt C
dc.contributor.authorBernlohr D
dc.contributor.authorBertrán E
dc.contributor.authorBindoli A
dc.contributor.authorBottari SP
dc.contributor.authorBrito PM
dc.contributor.authorCarrara G
dc.contributor.authorCasas AI
dc.contributor.authorChatzi A
dc.contributor.authorChondrogianni N
dc.contributor.authorConrad M
dc.contributor.authorCooke MS
dc.contributor.authorCosta JG
dc.contributor.authorCuadrado A
dc.contributor.authorMy-Chan Dang P
dc.contributor.authorDe Smet B
dc.contributor.authorDebelec-Butuner B
dc.contributor.authorDias IHK
dc.contributor.authorDunn JD
dc.contributor.authorEdson AJ
dc.contributor.authorGiniatullin R
dc.contributor.authoret al
dc.date.accessioned2017-11-08T14:18:53Z
dc.date.available2017-11-08T14:18:53Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/4486
dc.description.abstractThe European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.en
dc.language.isoENen
dc.publisherElsevier BVen
dc.relation.ispartofseriesRedox Biologyen
dc.relation.urihttp://dx.doi.org/10.1016/j.redox.2017.05.007en
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectReactive oxygen speciesen
dc.subjectReactive nitrogen speciesen
dc.subjectRedox signalingen
dc.subjectOxidative stressen
dc.subjectAntioxidantsen
dc.subjectRedox therapeuticsen
dc.titleEuropean contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)en
dc.description.versionpublished versionen
dc.contributor.departmentA.I. Virtanen -instituuttien
uef.solecris.id47673242en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1016/j.redox.2017.05.007en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange94-162en
dc.relation.issn2213-2317en
dc.relation.volume13en
dc.rights.accesslevelopenAccessen
dc.type.okmA2en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record