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dc.contributor.authorDali-Youcef, Nassim
dc.contributor.authorFroelich, Sébastien
dc.contributor.authorMoussallieh, François-Marie
dc.contributor.authorChibbaro, Salvatore
dc.contributor.authorNoël, Georges
dc.contributor.authorNamer, Izzie J.
dc.contributor.authorHeikkinen, Sami
dc.contributor.authorAuwerx, Johan
dc.date.accessioned2016-06-08T07:07:32Z
dc.date.available2016-06-08T07:07:32Z
dc.date.issued2015-03-20
dc.identifierdoi: 10.1038/srep09087
dc.identifier.citationNassim Dali-Youcef, Sébastien Froelich, François-Marie Moussallieh, Salvatore Chibbaro, Georges Noël, Izzie J. Namer, Sami Heikkinen & Johan Auwerx 2015. Scientific Reports 5, Article number: 9087.fi_FI
dc.identifier.issn2045-2322
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/48
dc.descriptionArticle
dc.description.abstractPrimary brain tumors are presently classified based on imaging and histopathological techniques, which remains unsatisfaying. We profiled here by quantitative real time PCR (qRT-PCR) the transcripts of eighteen histone deacetylases (HDACs) and a subset of transcriptional co-factors in non-tumoral brain samples from 15 patients operated for epilepsia and in brain tumor samples from 50 patients diagnosed with grade II oligodendrogliomas (ODII, n = 9), grade III oligodendrogliomas (ODIII, n = 22) and glioblastomas (GL, n = 19). Co-factor transcripts were significantly different in tumors as compared to non-tumoral samples and distinguished different molecular subgroups of brain tumors, regardless of tumor grade. Among all patients studied, the expression of HDAC1 and HDAC3 was inversely correlated with survival, whereas the expression of HDAC4, HDAC5, HDAC6, HDAC11 and SIRT1 was significantly and positively correlated with survival time of patients with gliomas. 1H-HRMAS technology revealed metabolomically distinct groups according to the expression of HDAC1, HDAC4 and SIRT1, suggesting that these genes may play an important role in regulating brain tumorigenesis and cancer progression. Our study hence identified different molecular fingerprints for subgroups of histopathologically similar brain tumors that may enable the prediction of outcome based on the expression level of co-factor genes and could allow customization of treatment.fi_FI
dc.language.isoenfi_FI
dc.publisherNature Publishing Groupfi_FI
dc.relation.ispartofseriesScientific Reports
dc.relation.urihttp://dx.doi.org/10.1038/srep09087
dc.rightsCC BY 4.0 https://creativecommons.org/licenses/by/4.0/
dc.subjectTranslational researchfi_FI
dc.subjectCancer genomicsfi_FI
dc.titleGene Expression Mapping of Histone Deacetylases and Co-factors, and Correlation with Survival Time and 1H-HRMAS Metabolomic Profile in Human Gliomas subtitle:fi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionPublisher's pdf
dc.contributor.departmentFaculty of Health Sciences
uef.solecris.id32464045
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Macmillan Publishers Limited, part of Springer Nature
dc.relation.doi10.1038/srep09087
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.relation.issn2045-2322
dc.relation.issue9087
dc.relation.volume5
dc.rights.accesslevelopenAccess


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