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dc.contributor.authorKunutsor SK
dc.contributor.authorWhitehouse MR
dc.contributor.authorBlom AW
dc.contributor.authorLaukkanen JA
dc.date.accessioned2017-11-17T07:42:24Z
dc.date.available2017-11-17T07:42:24Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/4904
dc.description.abstractMagnesium, which is an essential trace element that plays a key role in several cellular processes, is a major component of bone; however, its relationship with risk of major bone fractures is uncertain. We aimed to investigate the association of baseline serum magnesium concentrations with risk of incident fractures. We analyzed data on 2245 men aged 42–61 years in the Kuopio Ischemic Heart Disease prospective cohort study, with the assessment of serum magnesium measurements and dietary intakes made at baseline. Hazard ratios [95% confidence intervals (CI)] for incident total (femoral, humeral, and forearm) and femoral fractures were assessed. During a median follow-up of 25.6 years, 123 total fractures were recorded. Serum magnesium was non-linearly associated with risk of total fractures. In age-adjusted Cox regression analysis, the hazard ratio (HR) (95% CIs) for total fractures in a comparison of the bottom quartile versus top quartile of magnesium concentrations was 2.10 (1.30–3.41), which persisted on adjustment for several established risk factors 1.99 (1.23–3.24). The association remained consistent on further adjustment for renal function, socioeconomic status, total energy intake, and several trace elements 1.80 (1.10–2.94). The corresponding adjusted HRs for femoral fractures were 2.56 (1.38–4.76), 2.43 (1.30–4.53) and 2.13 (1.13–3.99) respectively. There was no evidence of an association of dietary magnesium intake with risk of any fractures. In middle-aged Caucasian men, low serum magnesium is strongly and independently associated with an increased risk of fractures. Further research is needed to assess the potential relevance of serum magnesium in the prevention of fractures.en
dc.language.isoENen
dc.publisherSpringer Natureen
dc.relation.ispartofseriesEUROPEAN JOURNAL OF EPIDEMIOLOGYen
dc.relation.urihttp://dx.doi.org/10.1007/s10654-017-0242-2en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectMagnesiumen
dc.subjectCohort studyen
dc.subjectFractureen
dc.subjectRisk factoren
dc.titleLow serum magnesium levels are associated with increased risk of fractures: a long-term prospective cohort studyen
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Medicine / Clinical Medicineen
uef.solecris.id47867087en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1007/s10654-017-0242-2en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange593–603en
dc.relation.issn0393-2990en
dc.relation.issue7en
dc.relation.volume32en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen


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