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dc.contributor.authorBawuah Prince
dc.contributor.authorPääkkönen Pertti
dc.contributor.authorPeiponen Kai-Erik
dc.date.accessioned2017-11-17T08:13:52Z
dc.date.available2017-11-17T08:13:52Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/4908
dc.description.abstractBackground The surface quality of pharmaceutical tablets plays an important role, especially in the drug release of a tablet and hence affects the bioavailability of the drug. Furthermore, important tablet’s properties such as coating uniformity and mechanical integrity that can be predicted based on the known surface properties manifest the inevitable link between a tablet’s surface property (e.g. Gloss, average surface roughness) and its efficacy. Methods In this article, laboratory based and handheld glossmeters as well as an optical profilometer were utilized for the detection of the surface properties of commercially available pharmaceutical tablets. Results As a case study, we measured the surface properties of authentic and counterfeit antimalarial tablets. Clear differences between authentic and fake tablets were detected based on the measured average surface roughness and gloss values of the tablet samples. Conclusions It is worth mentioning that this is the first time we have utilized both glossmeters for the purpose of surface quality investigation of real pharmaceutical tablets. It is therefore suggested that the handheld glossmeter is a useful device for quick inspection of tablet’s surface quality both in the production environments as well as for field screening of fake tablets.en
dc.language.isoENen
dc.publisherSpringer Natureen
dc.relation.ispartofseriesJournal of the European Optical Society - Rapid Publicationsen
dc.relation.urihttp://dx.doi.org/10.1186/s41476-017-0046-8en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectGlossen
dc.subjectSurface roughnessen
dc.subjectQuality screeningen
dc.subjectAntimalaria tabletsen
dc.subjectArtemetheren
dc.subjectLumefantrineen
dc.titleGloss measurement in detection of surface quality of pharmaceutical tablets: a case study of screening of genuine and counterfeit antimalaria tabletsen
dc.description.versionpublished versionen
dc.contributor.departmentDepartment of Physics and Mathematics, activitiesen
uef.solecris.id47867338en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1186/s41476-017-0046-8en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumber18en
dc.relation.issn1990-2573en
dc.relation.volume13en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen


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