Show simple item record

dc.contributor.authorMikkola Alma
dc.contributor.authorOjanen Aku
dc.contributor.authorHartikainen Juha EK
dc.contributor.authorRemes Anne M
dc.contributor.authorSimula Sakari
dc.date.accessioned2017-11-30T11:35:49Z
dc.date.available2017-11-30T11:35:49Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/5029
dc.description.abstractIntroduction Multiple sclerosis is associated with prolonged cardiac repolarization but the underlying physiology has remained unknown. In this study, we compared cardiac repolarization during the relapsing-remitting multiple sclerosis (RRMS) disease course in patients with motor and sensory onset symptom. Methods Twenty-five RRMS patients with motor and 33 RRMS patients with sensory onset symptom having 12-lead electrocardiogram (ECG) recorded at the time of the first demyelinating event (ECG1) as well as at the later disease course (ECG2) were identified from the patient records. The average time interval between ECG1 and ECG2 was 8.6 ± 5.9 y. Heart rate-corrected QT intervals reflecting cardiac repolarization were calculated by Bazett (QTcBaz), Fridericia (QTcFri), and Karjalainen (QTcKar) formulas. Results Heart rate-corrected QT intervals as well as heart rate were similar in patients with motor and sensory onset symptom in ECG1. However, QTcBaz (p = .002), QTcFri (p = .019), and QTcKar (p = .026) were longer and heart rate was higher (p = .035) in patients with motor than sensory onset symptom in ECG2. Correspondingly, QTcBaz (p = .002), QTcFri (p = .033), and QTcKar (p = .043) prolonged and heart rate tended to increase (p = .060) during the disease course only in the patients with motor onset symptom. Conclusions Cardiac repolarization prolonged and heart rate increased during the disease course in RRMS patients with motor but not with sensory onset symptom. This suggests different traits in RRMS according to its initial manifestation and also association of motor onset symptom with more unfavorable cardiovascular prognostic determinants.en
dc.language.isoENen
dc.publisherWiley-Blackwellen
dc.relation.ispartofseriesBrain and behavioren
dc.relation.urihttp://dx.doi.org/10.1002/brb3.742en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectautonomic nervous systemen
dc.subjectcardiac repolarizationen
dc.subjectmultiple sclerosisen
dc.subjectonset symptomen
dc.titleThe impact of multiple sclerosis onset symptom on cardiac repolarizationen
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Medicine / Clinical Medicineen
uef.solecris.id48257042en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1002/brb3.742en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumbere00742en
dc.relation.issn2162-3279en
dc.relation.issue7en
dc.relation.volume7en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record