Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs
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CitationPapathanasiou Konstantinos E. Turhanen Petri. Brueckner Stephan I. Brunner Eike. Demadis Konstantinos D. (2017). Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs. Scientific Reports, 7, 4743. 10.1038/s41598-017-04956-3.
Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-philicity/-phobicity, water-solubility), cations present, pH and temperature. These gels are robust, injectable, re-loadable and re-usable.