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dc.contributor.authorRahnasto-Rilla Minna K
dc.contributor.authorMcLoughlin Padraig
dc.contributor.authorKulikowicz Tomasz
dc.contributor.authorDoyle Maire
dc.contributor.authorBohr Vilhelm A
dc.contributor.authorLahtela-Kakkonen Maija
dc.contributor.authorFerrucci Luigi
dc.contributor.authorHayes Maria
dc.contributor.authorMoaddel Ruin
dc.date.accessioned2017-12-14T12:09:16Z
dc.date.available2017-12-14T12:09:16Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/5077
dc.description.abstractBrown seaweeds contain many bioactive compounds, including polyphenols, polysaccharides, fucosterol, and fucoxantin. These compounds have several biological activities, including anti-inflammatory, hepatoprotective, anti-tumor, anti-hypertensive, and anti-diabetic activity, although in most cases their mechanisms of action are not understood. In this study, extracts generated from five brown algae (Fucus dichitus, Fucus vesiculosus (Linnaeus), Cytoseira tamariscofolia, Cytoseira nodacaulis, Alaria esculenta) were tested for their ability to activate SIRT6 resulting in H3K9 deacetylation. Three of the five macroalgal extracts caused a significant increase of H3K9 deacetylation, and the effect was most pronounced for F. dichitus. The compound responsible for this in vitro activity was identified by mass spectrometry as fucoidan.en
dc.language.isoENen
dc.publisherMDPI AGen
dc.relation.ispartofseriesMarine Drugsen
dc.relation.urihttp://dx.doi.org/10.3390/md15060190en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectsirtuin activatorsen
dc.subjectfucoidanen
dc.subjectbrown seaweeden
dc.titleThe Identification of a SIRT6 Activator from Brown Algae Fucus distichusen
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Pharmacy, Activitiesen
uef.solecris.id49056491en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.3390/md15060190en
dc.description.reviewstatusnonPeerRevieweden
dc.relation.articlenumber190en
dc.relation.issn1660-3397en
dc.relation.issue6en
dc.relation.volume15en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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