Deregulation of the non-coding genome in leukemia
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CitationTeppo Susanna. Heinäniemi Merja. Lohi Olli. (2017). Deregulation of the non-coding genome in leukemia. RNA Biology, 14 (7) , 827-830. 10.1080/15476286.2017.1312228.
Methodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional changes after induction of a well-known leukemia-inducing fusion gene, ETV6-RUNX1. Our data revealed widespread transcriptional alterations outside coding elements in the genome. This adds to the growing list of various alterations in the non-coding genome in cancer and pinpoints their role in diseased cellular state.