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dc.contributor.authorTeppo Susanna
dc.contributor.authorHeinäniemi Merja
dc.contributor.authorLohi Olli
dc.date.accessioned2017-12-18T09:15:21Z
dc.date.available2017-12-18T09:15:21Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/5097
dc.description.abstractMethodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional changes after induction of a well-known leukemia-inducing fusion gene, ETV6-RUNX1. Our data revealed widespread transcriptional alterations outside coding elements in the genome. This adds to the growing list of various alterations in the non-coding genome in cancer and pinpoints their role in diseased cellular state.en
dc.language.isoENen
dc.publisherInforma UK Limiteden
dc.relation.ispartofseriesRNA Biologyen
dc.relation.urihttp://dx.doi.org/10.1080/15476286.2017.1312228en
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjecteRNAen
dc.subjectGRO-seqen
dc.subjectleukemiaen
dc.subjectnascent RNAen
dc.subjecttranscriptional regulationen
dc.titleDeregulation of the non-coding genome in leukemiaen
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Medicine / Biomedicineen
uef.solecris.id49139767en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1080/15476286.2017.1312228en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange827-830en
dc.relation.issn1547-6286en
dc.relation.issue7en
dc.relation.volume14en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessHybridijulkaisukanavassa ilmestynyt avoin julkaisu


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