Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
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CitationZillikens M Carola. Demissie Serkalem. Hsu Yi-Hsiang. Yerges-Armstrong Laura M. Chou Wen-Chi. Stolk Lisette. Livshits Gregory. Broer Linda. Johnson Toby. Koller Daniel L. Kutalik Zoltán. Luan Jian'an. Malkin Ida. Ried Janina S. Smith Albert V. Thorleifsson Gudmar. Vandenput Liesbeth. Zhao Jing Hua. Zhang Weihua. Aghdassi Ali et al. (incl. Cederberg Henna). (2017). Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nature Communications, 8, 80. 10.1038/s41467-017-00031-7.
Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10−8) or suggestively genome wide (p < 2.3 × 10−6). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.