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dc.contributor.authorSihvonen R
dc.contributor.authorPaavola M
dc.contributor.authorMalmivaara A
dc.contributor.authorItälä A
dc.contributor.authorJoukainen A
dc.contributor.authorNurmi H
dc.contributor.authorKalske J
dc.contributor.authorIkonen A
dc.contributor.authorJärvelä T
dc.contributor.authorJärvinen TA
dc.contributor.authorKanto K
dc.contributor.authorKarhunen J
dc.contributor.authorKnifsund J
dc.contributor.authorKröger H
dc.contributor.authorKääriäinen T
dc.contributor.authorLehtinen J
dc.contributor.authorNyrhinen J
dc.contributor.authorPaloneva J
dc.contributor.authorPäiväniemi O
dc.contributor.authorRaivio M et al.
dc.contributor.authorThe FIDELITY (Finnish Degenerative Meniscal Lesion Study) Investigators
dc.date.accessioned2018-01-03T13:58:25Z
dc.date.available2018-01-03T13:58:25Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/5121
dc.description.abstractObjective To assess if arthroscopic partial meniscectomy (APM) is superior to placebo surgery in the treatment of patients with degenerative tear of the medial meniscus. Methods In this multicentre, randomised, participant-blinded and outcome assessor-blinded, placebo-surgery controlled trial, 146 adults, aged 35–65 years, with knee symptoms consistent with degenerative medial meniscus tear and no knee osteoarthritis were randomised to APM or placebo surgery. The primary outcome was the between-group difference in the change from baseline in the Western Ontario Meniscal Evaluation Tool (WOMET) and Lysholm knee scores and knee pain after exercise at 24 months after surgery. Secondary outcomes included the frequency of unblinding of the treatment-group allocation, participants' satisfaction, impression of change, return to normal activities, the incidence of serious adverse events and the presence of meniscal symptoms in clinical examination. Two subgroup analyses, assessing the outcome on those with mechanical symptoms and those with unstable meniscus tears, were also carried out. Results In the intention-to-treat analysis, there were no significant between-group differences in the mean changes from baseline to 24 months in WOMET score: 27.3 in the APM group as compared with 31.6 in the placebo-surgery group (between-group difference, −4.3; 95% CI, −11.3 to 2.6); Lysholm knee score: 23.1 and 26.3, respectively (−3.2; −8.9 to 2.4) or knee pain after exercise, 3.5 and 3.9, respectively (−0.4; −1.3 to 0.5). There were no statistically significant differences between the two groups in any of the secondary outcomes or within the analysed subgroups. Conclusions In this 2-year follow-up of patients without knee osteoarthritis but with symptoms of a degenerative medial meniscus tear, the outcomes after APM were no better than those after placebo surgery. No evidence could be found to support the prevailing ideas that patients with presence of mechanical symptoms or certain meniscus tear characteristics or those who have failed initial conservative treatment are more likely to benefit from APM.en
dc.language.isoENen
dc.publisherBMJ Publishing Groupen
dc.relation.ispartofseriesANNALS OF THE RHEUMATIC DISEASESen
dc.relation.urihttp://dx.doi.org/10.1136/annrheumdis-2017-211172en
dc.rightsCC BY-NC http://creativecommons.org/licenses/by-nc/4.0/en
dc.titleArthroscopic partial meniscectomy versus placebo surgery for a degenerative meniscus tear: a 2-year follow-up of the randomised controlled trialen
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Medicine / Clinical Medicineen
uef.solecris.id48888635en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1136/annrheumdis-2017-211172en
dc.description.reviewstatuspeerRevieweden
dc.relation.issn0003-4967en
dc.relation.volume[Published online 18 May 2017]en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessHybridijulkaisukanavassa ilmestynyt avoin julkaisu


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